Role of serum vitamin A and E in pregnancy

Chen,Han; Qian,Nianfeng; Yan,Liyu; Jiang,Hongqing

doi:10.3892/etm.2018.6830

Role of serum vitamin A and E in pregnancy

Authors:
- Han Chen
- Nianfeng Qian
- Liyu Yan
- Hongqing Jiang
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Affiliations: Haidian Maternal and Child Health Hospital, Beijing 100080, P.R. China
Published online on: October 5, 2018 https://doi.org/10.3892/etm.2018.6830
Pages: 5185-5189
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Serum levels of vitamin A and E in early, middle and late pregnancy were analyzed to evaluate vitamin nutritional status in pregnancy, and provide guidance for pregnant women about vitamin supplements in pregnancy. In total, 28,023 serum samples were randomly selected from pregnant women in early, middle and late pregnancy between January 2013 and June 2014 in Beijing. High performance liquid chromatography (HPLC) method was used to determine the concentration of serum vitamin A and E in pregnancy. The concentration of serum vitamin A in early, middle and late pregnancy was 0.33±0.08, 0.37±0.09 and 0.33±0.15 mg/l, respectively, total abnormal rate was 25.31%, and deficiency (24.98%) was the main feature. The rate of deficiency in the early pregnancy (38.22%) was greater than that in late pregnancy (35.13%). The serum vitamin E in early, middle and late pregnancy was 9.10±2.47, 14.24±3.66 and 15.80±5.01 mg/l, respectively, total abnormal rate was 5.60%, and excess (5.37%) was the main feature. The excess rate in early pregnancy was at the lowest level (0.50%), and reached the highest level (15.32%) in late pregnancy. The serum levels of vitamin A and E are different during pregnancy. Generally, vitamin A is deficient and vitamin E is in excess. Therefore, monitoring the vitamin A and E levels, and strengthening perinatal education and providing guidance for pregnant women to supply vitamins rationally play important role in guaranteeing maternal and fetal safety.

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