Open Access

Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis

  • Authors:
    • Lei Zhong
    • Yuna Tong
    • Junlan Chuan
    • Lan Bai
    • Jianyou Shi
    • Yuxuan Zhu
  • View Affiliations

  • Published online on: February 4, 2019     https://doi.org/10.3892/etm.2019.7242
  • Pages: 2666-2674
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increased aggregation of β‑amyloid (Aβ) peptides induces oxidative stress, which is considered a major contributor in the development of Alzheimer's disease (AD). Prevention of Aβ‑induced neurotoxicity is proposed as a possible modality for treatment of AD. The present study aimed to elucidate possible effects of ethyl vanillin (EVA), an analog of vanillin isolated from vanilla beans, on the Aβ1‑42‑induced oxidative injury in PC12 cells. EVA restrained the decrease in PC12 cell viability and apoptosis induction caused by treatment with Aβ1‑42. In addition, EVA markedly alleviated intracellular lipid peroxidation as demonstrated by malondialdehyde levels and reactive oxygen species production in Aβ1‑42‑treated PC12 cells. In addition, the reduction in the activity levels of the antioxidative enzymes superoxide dismutase, catalase and glutathione peroxidase was detected in Aβ1‑42‑treated PC12 cells. This effect was partially reversed by treatment with EVA. Furthermore, the results indicated that EVA attenuated Aβ1‑42‑induced caspase‑3 activation and the increase noted in the apoptosis regulator Bcl‑2/apoptosis regulator Bax ratio of PC12 cells. These results indicated that EVA could be used as an efficient and novel agent for the prevention of neurodegenerative diseases via inhibition of oxidative stress and cell apoptosis.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhong L, Tong Y, Chuan J, Bai L, Shi J and Zhu Y: Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis. Exp Ther Med 17: 2666-2674, 2019.
APA
Zhong, L., Tong, Y., Chuan, J., Bai, L., Shi, J., & Zhu, Y. (2019). Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis. Experimental and Therapeutic Medicine, 17, 2666-2674. https://doi.org/10.3892/etm.2019.7242
MLA
Zhong, L., Tong, Y., Chuan, J., Bai, L., Shi, J., Zhu, Y."Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis". Experimental and Therapeutic Medicine 17.4 (2019): 2666-2674.
Chicago
Zhong, L., Tong, Y., Chuan, J., Bai, L., Shi, J., Zhu, Y."Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2666-2674. https://doi.org/10.3892/etm.2019.7242