Effectiveness of continuous veno-venous hemofiltration in the treatment of severe acute pancreatitis

Chen,Xuan; Sun,Meifang; Mao,Xiuhong; Liu,Xiaoxia; Sun,Weihe

doi:10.3892/etm.2019.7246

Effectiveness of continuous veno-venous hemofiltration in the treatment of severe acute pancreatitis

Authors:
- Xuan Chen
- Meifang Sun
- Xiuhong Mao
- Xiaoxia Liu
- Weihe Sun
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Affiliations: Department of Intensive Care Unit, Affiliated Dongtai Hospital of Nantong University, Dongtai, Jiangsu 224200, P.R. China, Department of Nursing, Affiliated Dongtai Hospital of Nantong University, Dongtai, Jiangsu 224200, P.R. China
Published online on: February 6, 2019 https://doi.org/10.3892/etm.2019.7246
Pages: 2720-2724
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Continuous veno-venous hemofiltration (CVVH) in the treatment of severe acute pancreatitis (SAP) was investigated. A total of 60 patients with SAP treated in the Affiliated Dongtai Hospital of Nantong University from October 2015 to October 2017 were enrolled in this retrospective study. Among them, 32 patients received CVVH and routine internal medicine therapy (the CVVH group), and 28 received routine internal medicine therapy (the control group). Then biochemical indexes and severity of SAP after treatment were detected to investigate the roles of CVVH and routine internal medicine therapy in treating SAP. Inflammatory factors in both the CVVH and control groups were significantly decreased after treatment (P<0.05), and CVVH could eliminate more factors. Comparison of blood biochemical indexes between the CVVH and control groups were carried out. Significant improvement was found (P<0.05) after CVVH and routine internal medicine therapy. Besides, Acute Physiology and Chronic Health Evaluation (APACHE)-II grade was significantly decreased in the CVVH group compared with that in the control group after 7 days. CVVH therapy can effectively reduce the levels of inflammatory factors in SAP patients, improve their biochemical and physiological indicators, and have high clinical application value.

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