Open Access

Positive acceleration adaptive training attenuates gastric ischemia‑reperfusion injury through COX‑2 and PGE2 expression

  • Authors:
    • Ying Chen
    • Jian‑Chang Wang
    • Chun‑Min Yang
    • Qin Fan
    • Jun Zheng
    • Hao Liu
  • View Affiliations

  • Published online on: February 19, 2019     https://doi.org/10.3892/etm.2019.7288
  • Pages: 2901-2906
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The mechanism involved in the effects of positive acceleration adaptive training (PAAT) on gastric ischemia‑reperfusion injury (GI‑RI) has not been fully characterized. The aim of the present study was to investigate the effects of PAAT in attenuating GI‑RI in a rat model. The inflammatory factor and caspase‑3 levels were measured using ELISA kits. A western blot assay was used to analyze tumor necrosis factor‑α (TNF)‑α, tumor necrosis factor receptor 1 (TNFR1), tumor necrosis factor‑related apoptosis inducing ligand (TRAIL), death receptor (DR) 4, DR5, cyclooxygenase (COX)‑2, COX‑1 and prostaglandin E2 (PGE2) protein expression levels. It was revealed that PAAT could alleviate GI‑RI and inflammatory factor levels in a rat model. PAAT suppressed TNF‑α and TNFR1 protein expression levels, inhibited TRAIL, DR4, DR5, COX‑2 and PGE2 protein expression levels; however, it did not have an effect on COX‑1 protein expression in the model of GI‑RI. The data indicated that the effects of PAAT attenuated GI‑RI through the downregulation of COX‑2 and PGE2 expression.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen Y, Wang JC, Yang CM, Fan Q, Zheng J and Liu H: Positive acceleration adaptive training attenuates gastric ischemia‑reperfusion injury through COX‑2 and PGE2 expression. Exp Ther Med 17: 2901-2906, 2019
APA
Chen, Y., Wang, J., Yang, C., Fan, Q., Zheng, J., & Liu, H. (2019). Positive acceleration adaptive training attenuates gastric ischemia‑reperfusion injury through COX‑2 and PGE2 expression. Experimental and Therapeutic Medicine, 17, 2901-2906. https://doi.org/10.3892/etm.2019.7288
MLA
Chen, Y., Wang, J., Yang, C., Fan, Q., Zheng, J., Liu, H."Positive acceleration adaptive training attenuates gastric ischemia‑reperfusion injury through COX‑2 and PGE2 expression". Experimental and Therapeutic Medicine 17.4 (2019): 2901-2906.
Chicago
Chen, Y., Wang, J., Yang, C., Fan, Q., Zheng, J., Liu, H."Positive acceleration adaptive training attenuates gastric ischemia‑reperfusion injury through COX‑2 and PGE2 expression". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2901-2906. https://doi.org/10.3892/etm.2019.7288