Paediatric virology and human papillomaviruses: An update

Mammas,Ioannis  N.; Dalianis,Tina; Doukas,Sotiros  G.; Zaravinos,Apostolos; Achtsidis,Vassilis; Thiagarajan,Prakash; Theodoridou,Maria; Spandidos,Demetrios  A.

doi:10.3892/etm.2019.7516

Paediatric virology and human papillomaviruses: An update

Authors:
- Ioannis N. Mammas
- Tina Dalianis
- Sotiros G. Doukas
- Apostolos Zaravinos
- Vassilis Achtsidis
- Prakash Thiagarajan
- Maria Theodoridou
- Demetrios A. Spandidos
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Affiliations: Department of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Karolinska Institutet, Karolinska University Hospital, SE-117 77 Stockholm, Sweden, Department of Surgery (Otolaryngology), Yale School of Medicine, New Haven, CT 06519, USA, Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus, Department of Ophthalmology, Royal Cornwall Hospitals NHS Trust, TR1 3LQ Cornwall, UK, Neonatal Unit, Division for Women and Children's Health, Noble's Hospital, IM4 4RJ Douglas, Isle of Man, British Isles, First Department of Paediatrics, ‘Aghia Sophia’ Children's Hospital, University of Athens School of Medicine, 115 27 Athens, Greece
Published online on: April 22, 2019 https://doi.org/10.3892/etm.2019.7516
Pages: 4337-4343
Copyright: © Mammas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Almost 10 years ago, in October, 2008, the scientist who reported for the first time the association between human papillomaviruses (HPV) and cervical cancer, was awarded with the Nobel prize. In the years that followed, Professor Harald zur Hausen actively supported the value of the HPV vaccination in the prevention of different types of cancer and highlighted the necessity of its introduction in both girls and boys. However, to date, in the majority of countries, HPV vaccination among male adolescents has not been implemented into the national vaccination schemes, while in several countries, including Greece, the participation rate to HPV vaccination among female adolescents still remains low. Recent data indicate that catch‑up HPV vaccination among young women has been extremely useful and has exhibited a significant effect in decreasing the prevalence of HPV. While the marketed current HPV vaccines prevent anogenital HPV infection, their impact on the natural history of oral HPV and their efficacy in preventing HPV‑related head and neck carcinomas need to be further investigated. Juvenile onset recurrent respiratory papillomatosis, as well as HPV‑associated conjunctival papillomas continue to be observed in childhood and their clinical management involves different therapeutic approaches with controversial outcomes. This review article provides an overview of recent views and advances on HPV infections and prevention in childhood that were presented at the ‘4th Workshop on Paediatric Virology' on Saturday September 22, 2018 in Athens, Greece.

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