Serum albumin is present at higher levels in alcoholic liver cirrhosis as compared to HCV-related cirrhosis
- Authors:
- Kazuhiro Kotoh
- Marie Fukushima
- Yuki Horikawa
- Shinsaku Yamashita
- Motoyuki Kohjima
- Makoto Nakamuta
- Munechika Enjoji
View Affiliations
Affiliations: Department of Hepatology and Pancreatology, Kyushu University Hospital, Fukuoka, Japan, Department of Gastroenterology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan, Health Care Center, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
- Published online on: October 19, 2011 https://doi.org/10.3892/etm.2011.370
-
Pages:
72-75
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Abstract
Residual hepatic functional reserve in cirrhotic patients is generally evaluated by a multivariate scoring system (Child-Pugh classification), which includes serum albumin levels as a variable. However, several patients show discrepancies between serum albumin levels and the progression of liver fibrosis, especially those with alcoholic cirrhosis. To assess whether hepatic capacity of protein synthesis varies with the etiology of cirrhosis, serum albumin and cholinesterase levels, and prothrombin time were compared between alcoholic cirrhosis and hepatitis C virus (HCV)-related cirrhosis. To minimize the influence of malnutrition and extrahepatic platelet destruction, patients with hepatocellular carcinoma, uncontrolled diabetes, appetite loss and/or splenal longitudinal size >15 cm were excluded. The patients with compensated liver cirrhosis were divided into three groups as follows: alcohol+/HCV+ (alcohol + HCV group; n=31), alcohol-/HCV+ (HCV group; n=31) and alcohol+/HCV- (alcohol group; n=27). These groups were adjusted with respect to age, gender, body mass index and platelet count. Serum albumin levels in the alcohol group were significantly higher than those in the HCV group, with a difference of approximately 0.5 g/dl in every class of platelet count. The correlation of the alcohol + HCV group was intermediate between the alcohol and HCV groups. On the other hand, the correlations between serum cholinesterase levels and platelet counts were similar among the three groups. The prothrombin time was also comparable among the groups. Accordingly, serum albumin levels were higher in patients with alcoholic cirrhosis and alcohol consumption should be carefully considered when evaluating
hepatic functional reserve.
View References
1.
|
A Di SarioG FeliciangeliE BendiaA
BenedettiDiagnosis of liver fibrosisEur Rev Med Pharmacol
Sci811182004
|
2.
|
EJ MullinMS MetcalfeGJ MaddernHow much
liver resection is too much?Am J
Surg1908797200510.1016/j.amjsurg.2005.01.04315972178
|
3.
|
J FazakasT MandliG TherEvaluation of liver
function for hepatic resectionTransplant
Proc38798800200610.1016/j.transproceed.2006.01.04816647474
|
4.
|
PD SchneiderPreoperative assessment of
liver functionSurg Clin North
Am84355373200410.1016/S0039-6109(03)00224-X
|
5.
|
DK ParkSH UmJW LeeClinical significance of
variceal hemorrhage in recent years in patients with liver
cirrhosis and esophageal varicesJ Gastroenterol
Hepatol1910421051200415304123
|
6.
|
X FornsS AmpurdanèsJM LlovetIdentification
of chronic hepatitis C patients without hepatic fibrosis by a
simple predictive
modelHepatology36986992200210.1053/jhep.2002.3612812297848
|
7.
|
CT WaiJK GreensonRJ FontanaJD
KalbfieischJA MarreroHS ConjeevaramAS LokA simple noninvasive index
can predict both significant fibrosis and cirrhosis in patients
with chronic hepatitis
CHepatology38518516200310.1053/jhep.2003.5034612883497
|
8.
|
F MangusoG D’AmbraA MenchiseR SollazzoL
D’AgostinoEffects of an appropriate oral diet on the nutritional
status of patients with HCV-related liver cirrhosis: a prospective
studyClin Nutr24751759200510.1016/j.clnu.2005.02.01016182039
|
9.
|
H WadenvikI DenforsJ KuttiSplenic blood
flow and intrasplenic platelet kinetics in relation to spleen
volumeBr J Haematol6718118519873676106
|
10.
|
K IzunoS FujiyamaJ ShibataK YoshidaT SatoO
ShimomuraM TakahashiTransrectal portal scintigraphy with I123
iodoamphetamine in liver
diseasesHepatogastroenterology38S8S111991
|
11.
|
C TatsumiM KudoK UeshimaNoninvasive
evaluation of hepatic fibrosis using serum fibrotic markers,
transient elastography (FibroScan) and real-time tissue
elastographyIntervirology512733200810.1159/000122602
|
12.
|
J PoniachikDE BernsteinKR ReddyLJ
JeffersME Coelho-LittleF CivantosER SchiffThe role of laparoscopy
in the diagnosis of cirrhosisGastrointest
Endosc43568571199610.1016/S0016-5107(96)70192-X8781934
|
13.
|
A RegevM BerhoLJ JeffersSampling error and
intra-observer variation in liver biopsy in patients with chronic
HCV infectionAm J
Gastroenterol9726142618200210.1111/j.1572-0241.2002.06038.x12385448
|
14.
|
RJ FontanaZG GoodmanJL
DienstagRelationship of serum fibrosis markers with liver fibrosis
stage and collagen content in patients with advanced chronic
hepatitis CHepatology47789798200810.1002/hep.2209918175357
|
15.
|
G AnnoniFR WeinerM ColomboMJ CzajaMA
ZernAlbumin and collagen gene regulation in alcohol- and
virus-induced human liver
diseaseGastroenterology9819720219902293578
|