Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus

  • Authors:
    • H. Ben-Hur
    • G. Kossoy
    • N. Kossoy
    • I. Zusman
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijmm.10.4.517
  • Pages: 517-521
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Abstract

We showed in a previous study that soluble low-molecular-mass tumor-associated antigens (sTAA) promote the anti-tumor effect of the anticancer drug cyclophosphamide (CPA) on rat mammary carcinogenesis. In this report, we analyzed the possible mechanism underlying this phenomenon. Studies were performed on the bone marrow and thymus from the following groups of rats: i) control rats, ii) rats treated with sTAA, iii) rats treated with CPA, iv) rats treated with CPA and sTAA. The cellular content of the bone marrow and thymus (CD4+ and CD8+ lymphocytes) was analyzed morphometrically and immunohistochemically. In the bone marrow, CPA caused significant substitution of cellular components with fatty tissue whereas sTAA repaired this process. We found that CPA affects mainly the process of myelogenesis whereas sTAA protect the production of lymphocytes. In the thymus, CPA alone or in combination with sTAA repaired the inhibition effect of DMBA on synthesis of CD4+ and CD8+ thymocytes. sTAA further increased the amount of CD8+ T lymphocytes in the medulla of the thymus. Data in the literature as well as the findings presented here demonstrate that the tested treatment, including vaccination with sTAA, actively promotes the generation of the host's antitumor immune response.

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October 2002
Volume 10 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ben-Hur H, Kossoy G, Kossoy N and Zusman I: Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. Int J Mol Med 10: 517-521, 2002.
APA
Ben-Hur, H., Kossoy, G., Kossoy, N., & Zusman, I. (2002). Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. International Journal of Molecular Medicine, 10, 517-521. https://doi.org/10.3892/ijmm.10.4.517
MLA
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10.4 (2002): 517-521.
Chicago
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10, no. 4 (2002): 517-521. https://doi.org/10.3892/ijmm.10.4.517