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Cloning and characterization of a novel splice variant of the brain-specific protein densin-180

  • Authors:
    • Liu Wang
    • Jian Xu
    • Qihan Wu
    • Jianfeng Dai
    • Xin Ye
    • Li Zeng
    • Chaoneng Ji
    • Shaohua Gu
    • Robert Chunhua Zhao
    • Yi Xie
    • Yumin Mao

  • View Affiliations

  • Published online on: February 1, 2003     https://doi.org/10.3892/ijmm.11.2.257
  • Pages: 257-260
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Densin-180 is a brain-specific synaptic protein of the o-sialoglycoprotein family. It functions in specific adhesion between presynaptic and postsynaptic membranes at glutamatergic synapses. We have cloned a novel splice variant of densin-180 from a fetal brain cDNA library and termed it LRRC7. It is located on 1p31 and consists of 8 exons. It encodes a putative protein of 216 amino acids which contains a nuclear localization signal and four leucine-rich repeats (LRRs). LRRs are 20-29 residue sequence motifs present in a number of proteins with diverse functions. Expression analysis of LRRC7 shows it is expressed ubiquitously while its splice variant densin-180 is brain-specific.

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Journal Cover

February 2003
Volume 11 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Wang L, Xu J, Wu Q, Dai J, Ye X, Zeng L, Ji C, Gu S, Zhao RC, Xie Y, Xie Y, et al: Cloning and characterization of a novel splice variant of the brain-specific protein densin-180. Int J Mol Med 11: 257-260, 2003
APA
Wang, L., Xu, J., Wu, Q., Dai, J., Ye, X., Zeng, L. ... Mao, Y. (2003). Cloning and characterization of a novel splice variant of the brain-specific protein densin-180. International Journal of Molecular Medicine, 11, 257-260. https://doi.org/10.3892/ijmm.11.2.257
MLA
Wang, L., Xu, J., Wu, Q., Dai, J., Ye, X., Zeng, L., Ji, C., Gu, S., Zhao, R. C., Xie, Y., Mao, Y."Cloning and characterization of a novel splice variant of the brain-specific protein densin-180". International Journal of Molecular Medicine 11.2 (2003): 257-260.
Chicago
Wang, L., Xu, J., Wu, Q., Dai, J., Ye, X., Zeng, L., Ji, C., Gu, S., Zhao, R. C., Xie, Y., Mao, Y."Cloning and characterization of a novel splice variant of the brain-specific protein densin-180". International Journal of Molecular Medicine 11, no. 2 (2003): 257-260. https://doi.org/10.3892/ijmm.11.2.257