Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma

  • Authors:
    • Masashi Higashimoto
    • Atsuko Kanzaki
    • Takeshi Shimakawa
    • Soichi Konno
    • Yoshihiko Naritaka
    • Yasutaka Nitta
    • Shiro Mori
    • Shinobu Shirata
    • Ayumi Yoshida
    • Kunihiko Terada
    • Toshihiro Sugiyama
    • Kenji Ogawa
    • Yuji Takebayashi
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijmm.11.3.337
  • Pages: 337-341
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A major obstacle in the treatment of esophageal carcinoma is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphatase (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the clinical significance of this transporter has not previously been addressed. Our goal was to investigate if ATP7B is expressed in esophageal carcinoma and whether its expression correlates with reduced responsiveness to cisplatin treatment. We retrospectively examined the expression of ATP7B in primary esophageal carcinoma and its association with chemotherapeutic effect. Tissues were surgically removed from 17 esophageal carcinoma patients. Twelve of them received cisplatin-based chemotherapy before surgery. We performed immunohistochemical analysis of ATP7B using a monoclonal antibody against ATP7B in 17 esophageal carcinomas. A variable degree of cytoplasmic staining of tumor cells was observed in 76.5% (13/17 cases) of the analyzed carcinomas. ATP7B expression was not observed in adjacent non-neoplastic tissues. ATP7B positivity was not significant in gender, age, histopathological grading or TNM categories. Patients with ATP7B-positive tumors tended to have an inferior response to chemotherapy compared with the patients with ATP7B-negative tumors. These findings suggest that overexpression of ATP7B in esophageal carcinoma could be associated with unfavorable clinical outcome in patients treated with cisplatin-based chemotherapy. Therefore, ATP7B gene expression might be considered as a chemoresistance marker for cisplatin in the patients of esophageal carcinoma and provider of important information on the strategy against esophageal carcinoma.

Related Articles

Journal Cover

March 2003
Volume 11 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Higashimoto M, Kanzaki A, Shimakawa T, Konno S, Naritaka Y, Nitta Y, Mori S, Shirata S, Yoshida A, Terada K, Terada K, et al: Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma. Int J Mol Med 11: 337-341, 2003
APA
Higashimoto, M., Kanzaki, A., Shimakawa, T., Konno, S., Naritaka, Y., Nitta, Y. ... Takebayashi, Y. (2003). Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma. International Journal of Molecular Medicine, 11, 337-341. https://doi.org/10.3892/ijmm.11.3.337
MLA
Higashimoto, M., Kanzaki, A., Shimakawa, T., Konno, S., Naritaka, Y., Nitta, Y., Mori, S., Shirata, S., Yoshida, A., Terada, K., Sugiyama, T., Ogawa, K., Takebayashi, Y."Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma". International Journal of Molecular Medicine 11.3 (2003): 337-341.
Chicago
Higashimoto, M., Kanzaki, A., Shimakawa, T., Konno, S., Naritaka, Y., Nitta, Y., Mori, S., Shirata, S., Yoshida, A., Terada, K., Sugiyama, T., Ogawa, K., Takebayashi, Y."Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma". International Journal of Molecular Medicine 11, no. 3 (2003): 337-341. https://doi.org/10.3892/ijmm.11.3.337