Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells

  • Authors:
    • Satoko Nakajima
    • Tetsuji Tanaka
    • Naohiko Umesaki
    • Osamu Ishiko
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijmm.11.3.353
  • Pages: 353-356
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Abstract

Leukemia inhibitory factor (LIF) is produced locally in decidual tissues, but its direct effects on endometrial stromal cells have not been well characterized. In this study, we examined the direct effects of LIF on normal human endometrial stromal cells using an in vitro decidualization assay system with 8-Br-cAMP, a decidualization inducer. We found no effects of LIF on cell viability and prolactin secretion of unstimulated endometrial stromal cells. LIF dose-dependently enhanced cell viability, but not prolactin secretion of 8-Br-cAMP-stimulated cells. LIF dose-dependently enhanced the viability of stromal cells co-stimulated with 8-Br-cAMP and LIF without any significant effect on PRL secretion from the cells. Further, the extracellular matrix did not affect these stimulatory effects of LIF on cell viability of 8-Br-cAMP-stimulated endometrial stromal cells. These results indicate that LIF enhances the cell viability of PRL-non-secreting 8-Br-cAMP-stimulated stromal cells, and that the cell survival signals generated by LIF are independent of those generated by the extracellular matrix. LIF produced locally in decidual tissues may enhance cell viability in certain activated endometrial stromal cells in an autocrine or paracrine manner, and possibly protect against cell damage during embryo implantation and trophoblastic invasion.

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March 2003
Volume 11 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nakajima S, Tanaka T, Umesaki N and Ishiko O: Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells. Int J Mol Med 11: 353-356, 2003
APA
Nakajima, S., Tanaka, T., Umesaki, N., & Ishiko, O. (2003). Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells. International Journal of Molecular Medicine, 11, 353-356. https://doi.org/10.3892/ijmm.11.3.353
MLA
Nakajima, S., Tanaka, T., Umesaki, N., Ishiko, O."Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells". International Journal of Molecular Medicine 11.3 (2003): 353-356.
Chicago
Nakajima, S., Tanaka, T., Umesaki, N., Ishiko, O."Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells". International Journal of Molecular Medicine 11, no. 3 (2003): 353-356. https://doi.org/10.3892/ijmm.11.3.353