Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV

  • Authors:
    • Mikako Fujita
    • Akiko Yoshida
    • Akiko Sakurai
    • Junko Tatsuki
    • Fumiko Ueno
    • Hirofumi Akari
    • Akio Adachi
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/ijmm.11.5.641
  • Pages: 641-644
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Abstract

Susceptibility of HSC-F, a cynomolgus macaque cell line immortalized by Herpesvirus saimiri, to infection with various primate immunodeficiency viruses were monitored. While NL432 clone of human immunodeficiency virus type 1 (HIV-1) did not grow at all in HSC-F cells, GH123 and GL-AN clones of HIV-2, and MA239 clone of simian immunodeficiency virus isolated from macaque monkeys (SIVMAC) did grow in these cells. In addition, NM-3 clone of a chimeric simian and human immunodeficiency virus (SHIV) grew fairly well in HSC-F cells. Mutational analyses of accessory genes of GL-AN were successfully performed in the HSC-F cells. These results have thus demonstrated the importance of this cell line for molecular biological studies on HIV/SIV.

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May 2003
Volume 11 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fujita M, Yoshida A, Sakurai A, Tatsuki J, Ueno F, Akari H and Adachi A: Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV. Int J Mol Med 11: 641-644, 2003.
APA
Fujita, M., Yoshida, A., Sakurai, A., Tatsuki, J., Ueno, F., Akari, H., & Adachi, A. (2003). Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV. International Journal of Molecular Medicine, 11, 641-644. https://doi.org/10.3892/ijmm.11.5.641
MLA
Fujita, M., Yoshida, A., Sakurai, A., Tatsuki, J., Ueno, F., Akari, H., Adachi, A."Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV". International Journal of Molecular Medicine 11.5 (2003): 641-644.
Chicago
Fujita, M., Yoshida, A., Sakurai, A., Tatsuki, J., Ueno, F., Akari, H., Adachi, A."Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV". International Journal of Molecular Medicine 11, no. 5 (2003): 641-644. https://doi.org/10.3892/ijmm.11.5.641