Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma

  • Authors:
    • Katsuya Shiraki
    • Kazushi Sugimoto
    • Yutaka Yamanaka
    • Yumi Yamaguchi
    • Yukiko Saitou
    • Keiichi Ito
    • Norihiko Yamamoto
    • Takenari Yamanaka
    • Katsuhiko Fujikawa
    • Kazumoto Murata
    • Takeshi Nakano
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/ijmm.12.5.705
  • Pages: 705-708
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Abstract

The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of apoptosis. Since suppression of apoptosis is fundamentally important for carcinogenesis and tumor growth, we investigated the expression and function of XIAP in human hepatocellular carcinomas (HCCs). XIAP was expressed constitutively in HCC cell lines. Fourteen out of 20 (70%) HCC tissues demonstrated moderate or strong cytoplasmic staining for XIAP, whereas non-tumor parts showed negative or weak staining for XIAP by immunohistochemistry. In addition, XIAP expression was inversely correlated with apoptosis, but not with proliferation in HCC tissues. These results indicated that XIAP is a principal inhibitor of apoptosis overexpressed in human HCCs and that XIAP may be a potential target for gene therapy of human HCCs.

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November 2003
Volume 12 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Shiraki K, Sugimoto K, Yamanaka Y, Yamaguchi Y, Saitou Y, Ito K, Yamamoto N, Yamanaka T, Fujikawa K, Murata K, Murata K, et al: Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma. Int J Mol Med 12: 705-708, 2003
APA
Shiraki, K., Sugimoto, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Ito, K. ... Nakano, T. (2003). Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma. International Journal of Molecular Medicine, 12, 705-708. https://doi.org/10.3892/ijmm.12.5.705
MLA
Shiraki, K., Sugimoto, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Ito, K., Yamamoto, N., Yamanaka, T., Fujikawa, K., Murata, K., Nakano, T."Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma". International Journal of Molecular Medicine 12.5 (2003): 705-708.
Chicago
Shiraki, K., Sugimoto, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Ito, K., Yamamoto, N., Yamanaka, T., Fujikawa, K., Murata, K., Nakano, T."Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma". International Journal of Molecular Medicine 12, no. 5 (2003): 705-708. https://doi.org/10.3892/ijmm.12.5.705