Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells

  • Authors:
    • Hong-Lok Lung
    • Wai-Ki Ip
    • Zhen-Yu Chen
    • Nai-Ki Mak
    • Kwok-Nam Leung
  • View Affiliations

  • Published online on: March 1, 2004     https://doi.org/10.3892/ijmm.13.3.465
  • Pages: 465-471
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Abstract

Among the black tea polyphenols, theaflavins are generally considered to be the more effective components for the inhibition of carcinogenesis. In this study, we attempted to compare the growth-inhibitory and apoptosis-inducing activities of the four black tea theaflavins (TF-1, TF-2A, TF-2B and TF-3) with the major green tea catechin epigallocatechin-3-gallate (EGCG) on the murine myeloid leukemia WEHI-3B JCS cells. All the four black tea theaflavins were shown to exert potent anti-proliferative and cytotoxic effects on the leukemia WEHI-3B JCS cells in a dose-dependent manner. The observed anti-proliferative and cytotoxic effects were in the following order of potency: EGCG > TF-2B > TF-3 > TF-2A > TF-1. In addition, all theaflavins were capable of inducing apoptosis in the leukemia WEHI-3B JCS cells. Among the four theaflavins tested, TF-2B and TF-3 were found to be slightly more potent in inducing apoptosis of the WEHI-3B JCS cells than that of TF-2A and TF-1 but were comparable to the major green tea epicatechin EGCG. More interestingly, both TF-2B and TF-3 were found to be much more effective than TF-1 and TF-2B in reducing both the in vitro clonogenicity and in vivo tumorigenicity of the WEHI-3B JCS cells, suggesting that these two black tea theaflavins might represent potential candidates for the treatment of some forms of leukemia.

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March 2004
Volume 13 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lung H, Ip W, Chen Z, Mak N and Leung K: Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. Int J Mol Med 13: 465-471, 2004
APA
Lung, H., Ip, W., Chen, Z., Mak, N., & Leung, K. (2004). Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. International Journal of Molecular Medicine, 13, 465-471. https://doi.org/10.3892/ijmm.13.3.465
MLA
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13.3 (2004): 465-471.
Chicago
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13, no. 3 (2004): 465-471. https://doi.org/10.3892/ijmm.13.3.465