A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation

  • Authors:
    • Toshiaki Takahashi
    • Yasuhiro Ogawa
    • Toshihiro Kobayashi
    • Hiroshi Sonobe
    • Harumichi Seguchi
    • Toshikazu Tani
    • Shoji Yoshida
  • View Affiliations

  • Published online on: September 1, 2004     https://doi.org/10.3892/ijmm.14.3.405
  • Pages: 405-408
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Abstract

We investigated whether a combination of selective COX-2 inhibitors and hydrogen peroxide increases the effect of X-ray irradiation, with regard to reactive oxygen species (ROS) formation in an osteosarcoma cell line. COX-2 inhibitor did not induce ROS formation when combined with irradiation. A low dose concentration of COX-2 inhibitor in combination with hydrogen peroxide and irradiation did affect ROS formation in the intracellular compartment; however, this same combination of agents at high doses did not modulate the effect of irradiation. Therefore, low doses of COX-2 inhibitor and hydrogen peroxide together, in combination with irradiation, is a potentially useful alternative form of radiotherapy for apoptotic-resistant neoplasms such as osteosarcoma.

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September 2004
Volume 14 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takahashi T, Ogawa Y, Kobayashi T, Sonobe H, Seguchi H, Tani T and Yoshida S: A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. Int J Mol Med 14: 405-408, 2004
APA
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., & Yoshida, S. (2004). A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. International Journal of Molecular Medicine, 14, 405-408. https://doi.org/10.3892/ijmm.14.3.405
MLA
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., Yoshida, S."A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation". International Journal of Molecular Medicine 14.3 (2004): 405-408.
Chicago
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., Yoshida, S."A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation". International Journal of Molecular Medicine 14, no. 3 (2004): 405-408. https://doi.org/10.3892/ijmm.14.3.405