Blood antioxidant parameters in patients with diabetic retinopathy

  • Authors:
    • Krzysztof Siemianowicz
    • Jan Gminski
    • Alicja Telega
    • Aneta Wójcik
    • Barbara Posielezna
    • Rozalia Grabowska-Bochenek
    • Tomasz Francuz
  • View Affiliations

  • Published online on: September 1, 2004     https://doi.org/10.3892/ijmm.14.3.433
  • Pages: 433-437
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Abstract

It has been postulated that enhanced generation of reactive oxygen species (ROS) may take part in a pathogenesis of diabetic microvascular complication - retinopathy. There are two types of diabetic retinopathy, non-proliferative (simplex) and proliferative. ROS are anihilated by an intracelluar enzymatic system composed mainly of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT). Beta-carotene, tocopherols and ascorbic acid are major components of serum antioxidants. All serum antioxidants are usually measured together as total antioxidant status (TAS). Erythrocyte activities of GPx, SOD, CAT and TAS were measured in diabetic patients without retinopathy, with non-proliferative and proliferative retinopathy. Obtained results were correlated with a period of diabetic history and a period of insulin treatment. SOD was significantly elevated in diabetics with non-proliferative retinopathy compared to patients without retinopathy. TAS was significantly lower in patients with proliferative retinopathy than in diabetics not developing retinopathy. Only CAT was significantly negatively correlated with the period of insulin treatment. This significant negative correlation was also observed in a subgroup of patients with proliferative retinopathy.

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September 2004
Volume 14 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Siemianowicz K, Gminski J, Telega A, Wójcik A, Posielezna B, Grabowska-Bochenek R and Francuz T: Blood antioxidant parameters in patients with diabetic retinopathy. Int J Mol Med 14: 433-437, 2004
APA
Siemianowicz, K., Gminski, J., Telega, A., Wójcik, A., Posielezna, B., Grabowska-Bochenek, R., & Francuz, T. (2004). Blood antioxidant parameters in patients with diabetic retinopathy. International Journal of Molecular Medicine, 14, 433-437. https://doi.org/10.3892/ijmm.14.3.433
MLA
Siemianowicz, K., Gminski, J., Telega, A., Wójcik, A., Posielezna, B., Grabowska-Bochenek, R., Francuz, T."Blood antioxidant parameters in patients with diabetic retinopathy". International Journal of Molecular Medicine 14.3 (2004): 433-437.
Chicago
Siemianowicz, K., Gminski, J., Telega, A., Wójcik, A., Posielezna, B., Grabowska-Bochenek, R., Francuz, T."Blood antioxidant parameters in patients with diabetic retinopathy". International Journal of Molecular Medicine 14, no. 3 (2004): 433-437. https://doi.org/10.3892/ijmm.14.3.433