Expression and regulation of RB1CC1 in developing murine and human tissues.

  • Authors:
    • Noriko Bamba
    • Tokuhiro Chano
    • Takashi Taga
    • Shigeru Ohta
    • Yoshihiro Takeuchi
    • Hidetoshi Okabe
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijmm.14.4.583
  • Pages: 583-590
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

RB1-inducible coiled-coil 1 (RB1CC1) is a novel molecule implicated in the regulation of RB1 (retinoblastoma 1) expression. However, information about the RB1CC1 gene is limited and its function remains somewhat obscure. The present study analyzes the expression and promoter activities of RB1CC1 in developing murine and human tissues. Rb1cc1 was abundantly expressed from an early stage of the mouse embryo throughout development. Immunohistochemical analyses revealed that Rb1cc1 was ubiquitous in the mouse, rather than in the human embryo, especially in the musculoskeletal system, heart and neural tissues. Promoter activity was highest in a region located about 300 bp immediately upstream of exon 1 in both the mouse and human RB1CC1 genes, suggesting that this region is a core promoter. The promoter activity of RB1CC1 was generally higher in mice than in humans, and suppressive with intron 1, especially in humans. These results suggested that more Rb1cc1 is expressed throughout developing murine than in human tissues, and that RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice.

Related Articles

Journal Cover

October 2004
Volume 14 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Bamba, N., Chano, T., Taga, T., Ohta, S., Takeuchi, Y., & Okabe, H. (2004). Expression and regulation of RB1CC1 in developing murine and human tissues.. International Journal of Molecular Medicine, 14, 583-590. https://doi.org/10.3892/ijmm.14.4.583
MLA
Bamba, N., Chano, T., Taga, T., Ohta, S., Takeuchi, Y., Okabe, H."Expression and regulation of RB1CC1 in developing murine and human tissues.". International Journal of Molecular Medicine 14.4 (2004): 583-590.
Chicago
Bamba, N., Chano, T., Taga, T., Ohta, S., Takeuchi, Y., Okabe, H."Expression and regulation of RB1CC1 in developing murine and human tissues.". International Journal of Molecular Medicine 14, no. 4 (2004): 583-590. https://doi.org/10.3892/ijmm.14.4.583