Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients

  • Authors:
    • Yu Yang
    • Min-Tsung Kao
    • Chia-Chu Chang
    • Shyi-Yu Chung
    • Chih-Mei Chen
    • Jeffrey J.P. Tsai
    • Jan-Gowth Chang
  • View Affiliations

  • Published online on: November 1, 2004     https://doi.org/10.3892/ijmm.14.5.855
  • Pages: 855-859
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Reactive oxygen metabolites may contribute to the development of end-stage renal disease (ESRD) in diabetic and hypertensive patients. In this study, we used multiplex polymerase chain reaction (PCR) to analyze polymorphisms of two endogenous antioxidant genes, glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1), and to determine their role in the development of ESRD in diabetic and hypertensive patients. Our results showed that homozygous deletion of the GSTT1 gene is a risk factor for developing ESRD in diabetic patients (p=0.004, OR=2.18, 95% confidence interval (CI) =1.29-3.70), but not in hypertensive patients. No association between homozygous deletion of GSTM1 and the development of ESRD was found in either diabetic patients or hypertensive patients. These results indicate that genetic variations in enzymes involved in free radical metabolism are associated with the development of ESRD in diabetes mellitus (DM) patients, and may permit the targeting of preventive and early intervention strategies to high-risk individuals.

Related Articles

Journal Cover

November 2004
Volume 14 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Kao M, Chang C, Chung S, Chen C, Tsai JJ and Chang J: Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients. Int J Mol Med 14: 855-859, 2004.
APA
Yang, Y., Kao, M., Chang, C., Chung, S., Chen, C., Tsai, J.J., & Chang, J. (2004). Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients. International Journal of Molecular Medicine, 14, 855-859. https://doi.org/10.3892/ijmm.14.5.855
MLA
Yang, Y., Kao, M., Chang, C., Chung, S., Chen, C., Tsai, J. J., Chang, J."Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients". International Journal of Molecular Medicine 14.5 (2004): 855-859.
Chicago
Yang, Y., Kao, M., Chang, C., Chung, S., Chen, C., Tsai, J. J., Chang, J."Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients". International Journal of Molecular Medicine 14, no. 5 (2004): 855-859. https://doi.org/10.3892/ijmm.14.5.855