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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2004 Volume 14 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer

C. Parr, G. Watkins, W. G. Jiang
Pages: 779-786
Published online on: 01 November 2004

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Article

Co-expression of VEGF, c-Met and HGF/SF in secondary pleural tumors

Ramin Naim, Edina Tolnay, Klaus-Michael Mueller, Cornelius Kuhnen
Pages: 787-791
Published online on: 01 November 2004

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Article

Analysis of the PTCH1 signaling pathway in ovarian dermoids

Sonja Levanat, Roland Kappler, Bernhard Hemmerlein, Patrick Döring, Vesna Musani, Arijana Komar, Slavko Oreskovic, Bozidar Pavelic, Heidi Hahn
Pages: 793-799
Published online on: 01 November 2004

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Article

Stable long-term induction of perforin-positive CD8+ T cells in gut by oral administration of streptococcal preparation OK-432

Norifumi Mino, Yoshio Naomoto, Yasuhiro Shirakawa, Junji Matsuoka, Tetsuji Nobuhisa, Mehmet Gunduz, Kazuhiro Noma, Hitoshi Nagatsuka, Masahiko Kobayashi, Tomoki Yamatsuji, Minoru Haisa, Akira Gochi, Noriaki Tanaka
Pages: 801-806
Published online on: 01 November 2004

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Article

Hypermethylation of the p16 gene in normal oral mucosa of smokers

S. Ventorin von Zeidler, E. C. Miracca, M. A. Nagai, E. G. Birman
Pages: 807-811
Published online on: 01 November 2004

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Article

Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor-associated periodic syndrome and with systemic lupus erythematosus in Japanese

Takahiko Horiuchi, Hiroshi Tsukamoto, Hiroki Mitoma, Hiroshi Miyagawa, Yasuhiro Tamimoto, Seiji Yoshizawa, Mine Harada, Kenshi Hayashi, Chinami Hashimura, Motohiro Oribe, Seiichi Okamura
Pages: 813-818
Published online on: 01 November 2004

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Article

Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells

Kiminori Matsubara, Masaharu Mori, Reiko Akagi, Norihisa Kato
Pages: 819-823
Published online on: 01 November 2004

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Article

Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis

Thilo Schlott, Thomas Quentin, Monika Korabiowska, Bettina Budd, Ekkehard Kunze
Pages: 825-836
Published online on: 01 November 2004

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Article

Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats

Satoru Tsuruta, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Kenichi Hiasa, Kensuke Egashira, Hajime Nawata
Pages: 837-842
Published online on: 01 November 2004

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Article

Effects of neuropeptides B and W on the secretion and growth of rat adrenocortical cells

Anna Hochol, Giovanna Albertin, Gastone G. Nussdorfer, Raffaella Spinazzi, Agnieszka Ziolkowska, Marcin Rucinski, Ludwik K. Malendowicz
Pages: 843-847
Published online on: 01 November 2004

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Article

Ghrelin inhibits in vitro angiogenic activity of rat brain microvascular endothelial cells

Silvia Baiguera, Maria Terresa Conconi, Diego Guidolin, Giuseppina Mazzocchi, Ludwik K. Malendowicz, Pier Paolo Parnigotto, Raffaella Spinazzi, Gastone G. Nussdorfer
Pages: 849-854
Published online on: 01 November 2004

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Article

Glutathione S-transferase T1 deletion is a risk factor for developing end-stage renal disease in diabetic patients

Yu Yang, Min-Tsung Kao, Chia-Chu Chang, Shyi-Yu Chung, Chih-Mei Chen, Jeffrey J.P. Tsai, Jan-Gowth Chang
Pages: 855-859
Published online on: 01 November 2004

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Article

The Notch ligand, Delta-1, reduces TNF-α-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells

Mai Murata-Ohsawa, Shuji Tohda, Hanae Kogoshi, Nobuo Nara
Pages: 861-866
Published online on: 01 November 2004

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Article

Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101

Masaki Hiramoto, Yutaka Kawakami, Ryusuke Nabeshima, Daisuke Shima, Hiroshi Handa, Shin Aizawa
Pages: 867-872
Published online on: 01 November 2004

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Article

Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells

Ludwik K. Malendowicz, Raffaella Spinazzi, Cinzia Tortorella, Gastone G. Nussdorfer, Agnieszka Ziolkowska, Marcin Rucinski
Pages: 873-877
Published online on: 01 November 2004

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Article

In vitro and in vivo anti-allergic activity of soy sauce

Makio Kobayashi, Hiroaki Matsushita, Kazutoshi Yoshida, Ryo-Ichi Tsukiyama, Takashi Sugimura, Kenji Yamamoto
Pages: 879-884
Published online on: 01 November 2004

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Article

Quality of life improvement with soy sauce ingredients, Shoyu polysaccharides, in perennial allergic rhinitis: A double-blind placebo-controlled clinical study

Makio Kobayashi, Hiroaki Matsushita, Ikuo Shioya, Mitsuyori Nagai, Ryo-Ichi Tsukiyama, Masami Saito, Toshiro Sugita, Takashi Sugimura, Kenji Yamamoto
Pages: 885-889
Published online on: 01 November 2004

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Article

Expression of albumin in bone tissues and osteoblastic cells: Involvement of hormonal regulation

Koichi Ishida, Natsumi Sawada, Masayoshi Yamaguchi
Pages: 891-895
Published online on: 01 November 2004

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Article

Molecular and morphometric description of adipose tissue during weight changes: A quantitative tool for assessment of tissue texture

Claudio Pagano, Alessandra Calcagno, Luciano Giacomelli, Alessandro Poletti, Veronica Macchi, Roberto Vettor, Raffaele De Caro, Giovanni Federspil
Pages: 897-902
Published online on: 01 November 2004

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Article

Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes

Theru A. Sivakumaran, Marci M. Lesperance
Pages: 903-907
Published online on: 01 November 2004

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Review

Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review)

Inbal Azran, Yana Schavinsky-Khrapunsky, Esther Priel, Mahmoud Huleihel, Mordechai Aboud
Pages: 909-915
Published online on: 01 November 2004

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Article

Characterization of polysaccharides from the flowers of Nerium indicum and their neuroprotective effects

Man-Shan Yu, Sau-Wan Lai, Kim-Fung Lin, Ji-Nian Fang, Wai-Hung Yuen, Raymond Chuen-Chung Chang
Pages: 917-924
Published online on: 01 November 2004

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Article

Growth inhibitory potential of effective microorganism fermentation extract (EM-X) on cancer cells

Chung Hin Chui, Gregory Yin Ming Cheng, Bin Ke, Fung Yi Lau, Raymond Siu Ming Wong, Stanton Hon Lung Kok, Sarwat Fatima, Filly Cheung, Chor Hing Cheng, Albert Sun Chi Chan, Johnny Cheuk On Tang
Pages: 925-929
Published online on: 01 November 2004

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Article

Targeting metastatic leiomyosarcoma by rapamycin plus gemcitabine: An intriguing clinical observation

Ofer Merimsky
Pages: 931-935
Published online on: 01 November 2004

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Article

Impaired apoptosis of lymphocytes derived from patient with decreased expression of caspase-8 results in Alps-like phenotype

Tomasz Grzela, Agnieszka Krauze, Katarzyna Grzela, Maciej Lazarczyk, Justyna Niderla, Robert Brawura-Biskupski-Samaha, Piotr Dziunycz, Lukasz Milewski, Grazyna Korczak-Kowalska, Marek Kulus
Pages: 937-942
Published online on: 01 November 2004

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Article

Identification and characterization of ARHGAP27 gene in silico

Yuriko Katoh, Masaru Katoh
Pages: 943-947
Published online on: 01 November 2004

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Article

Characterization of human FOXN4 gene in silico

Masuko Katoh, Masaru Katoh
Pages: 949-953
Published online on: 01 November 2004

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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Article Open Access

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Article Open Access

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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Review Open Access

High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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Article Open Access

ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Review Open Access

Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Review Open Access

Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Published online on: 01 December 2025

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