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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2005 Volume 15 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity

  • Authors:
    • Hironobu Tsukada
    • Aya Fukui
    • Tadayuki Tsujita
    • Misako Matsumoto
    • Takaji Iida
    • Tsukasa Seya

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan
  • Pages: 519-525
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/ijmm.15.3.519
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Abstract

From an EST fragment of the rainbow trout that was predicted to contain leucine-rich repeats (LRR), we cloned the whole cDNA and identified a soluble form of TLR5 ortholog (rtTLR5S), which does not exist in the mouse and human. rtTLR5S was about 38% homologous to the extracellular domains of human (hu) and mouse (mo)TLR5, while rtTLR5S showed <25% homologous to those of other human or mouse TLRs. A chimera constructed of rtTLR5S and the intra-cellular TIR of huTLR5 expressed on HeLa cells signaled the presence of flagellin A and C from V. anguillarum, resulting in NF-κB activation. The mRNA of rtTLR5S was predominantly detected in the liver. The hepatoma cell line of the rainbow trout RTH149 that responded to flagellin, allowed to up-regulate rtTLR5S in response to V. anguillarum or its purified flagellin within 8 h. rtTLR5S, when co-expressed with membrane huTLR5 in HeLa cells, augmented huTLR5-mediated NF-κB activation in response to flagellin. These results, together with the genome information of the pufferfish Fugu (Fugu rubripes), suggest that in fish the soluble TLR5 is an acute-phase protein sensing bacterial infection via recognition of a variety of bacterial flagellins to augment NF-κB activation, and may be important for fish to survive from bacterial infection in the water.

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Copy and paste a formatted citation
Spandidos Publications style
Tsukada H, Fukui A, Tsujita T, Matsumoto M, Iida T and Seya T: Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. Int J Mol Med 15: 519-525, 2005.
APA
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., & Seya, T. (2005). Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. International Journal of Molecular Medicine, 15, 519-525. https://doi.org/10.3892/ijmm.15.3.519
MLA
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., Seya, T."Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity". International Journal of Molecular Medicine 15.3 (2005): 519-525.
Chicago
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., Seya, T."Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity". International Journal of Molecular Medicine 15, no. 3 (2005): 519-525. https://doi.org/10.3892/ijmm.15.3.519
Copy and paste a formatted citation
x
Spandidos Publications style
Tsukada H, Fukui A, Tsujita T, Matsumoto M, Iida T and Seya T: Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. Int J Mol Med 15: 519-525, 2005.
APA
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., & Seya, T. (2005). Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. International Journal of Molecular Medicine, 15, 519-525. https://doi.org/10.3892/ijmm.15.3.519
MLA
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., Seya, T."Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity". International Journal of Molecular Medicine 15.3 (2005): 519-525.
Chicago
Tsukada, H., Fukui, A., Tsujita, T., Matsumoto, M., Iida, T., Seya, T."Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity". International Journal of Molecular Medicine 15, no. 3 (2005): 519-525. https://doi.org/10.3892/ijmm.15.3.519
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