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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2005 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2005 Volume 16 Issue 1

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Article

Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages

  • Authors:
    • Hai-Long Li
    • Hai-Long Chen
    • Hong Li
    • Kai-Li Zhang
    • Xiao-Yan Chen
    • Xiao-Wei Wang
    • Qing-You Kong
    • Jia Liu

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian, P.R. China
  • Pages: 41-47
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/ijmm.16.1.41
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Abstract

Emodin, an anthraquinones component of Rheum palmatun, has been used for anti-inflammatory purposes. However, its underlying molecular effect(s) on target cells remain to be well clarified. Thus, our current study was aimed at investigating the regulatory mechanism of emodin on liposaccharide-induced inflammatory responses in RAW 264.7 macrophages by RT-PCR, Western blot analysis, immunocytochemical staining and immunofluorescence analysis. It was found that a treatment of 20 µg/ml emodin inhibited the expression of a panel of inflammatory-associated genes, including TNFα, iNOS, IL-10, cytosolic IκBα, IKK-α and IKK-γ, to different extents as well as the nuclear translocation of NF-κB (nuclear factor-κB). The promoting effect of emodin on the production and translocation of p105 (the precursor of NF-κB p50) was time-dependent and reached a maximum at 5 h. Our data suggest that emodin plays its anti-inflammatory roles by regulating inflammatory cytokines, specifically by suppressing NF-κB activation.

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Chen H, Li H, Zhang K, Chen X, Wang X, Kong Q and Liu J: Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int J Mol Med 16: 41-47, 2005.
APA
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X. ... Liu, J. (2005). Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages. International Journal of Molecular Medicine, 16, 41-47. https://doi.org/10.3892/ijmm.16.1.41
MLA
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X., Kong, Q., Liu, J."Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages". International Journal of Molecular Medicine 16.1 (2005): 41-47.
Chicago
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X., Kong, Q., Liu, J."Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages". International Journal of Molecular Medicine 16, no. 1 (2005): 41-47. https://doi.org/10.3892/ijmm.16.1.41
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Chen H, Li H, Zhang K, Chen X, Wang X, Kong Q and Liu J: Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int J Mol Med 16: 41-47, 2005.
APA
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X. ... Liu, J. (2005). Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages. International Journal of Molecular Medicine, 16, 41-47. https://doi.org/10.3892/ijmm.16.1.41
MLA
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X., Kong, Q., Liu, J."Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages". International Journal of Molecular Medicine 16.1 (2005): 41-47.
Chicago
Li, H., Chen, H., Li, H., Zhang, K., Chen, X., Wang, X., Kong, Q., Liu, J."Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages". International Journal of Molecular Medicine 16, no. 1 (2005): 41-47. https://doi.org/10.3892/ijmm.16.1.41
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