P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism

  • Authors:
    • Witold Chudzinski
    • Justyna Niderla
    • Zofia Lasiecka
    • Grzegorz Wilczynski
    • Barbara Gornicka
    • Aleksander Wasiutynski
    • Joanna Maczewska
    • Malgorzata Kobylecka
    • Leszek Krolicki
    • Magdalena Durlik
    • Ewa Nowacka
    • Maciej Lazarczyk
    • Piotr Dziunycz
    • Lukasz Milewski
    • Ireneusz Nawrot
    • Tomasz Grzela
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/ijmm.16.2.215
  • Pages: 215-219
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Precise localization of parathyroid glands using 99mTc-labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy could be affected by various biological factors. There is increasing evidence that radiotracer retention could be controlled by members of multidrug resistance (MDR) system, especially P-glycoprotein (P-gp). Since the role of P-gp in tertiary hyperparathyroidism (T-HPTH) scintigraphic studies is poorly recognized, the aim of the study was to compare the correlation between parathyroid P-gp expression and results of their scintigraphy in T-HPTH versus primary hyperparathyroidism (P-HPTH). P-HPTH (n=19) and T-HPTH (n=18) patients were subjected to 99mTc-MIBI scintigraphy followed by surgical treatment. The parathyroid glands were assessed in routine hematoxylin-eosin staining and P-gp expression was analyzed using immunohistochemistry. Parathyroids collected during cadaver donor multi-organ harvesting were used as a control. It has been found that P-HPTH-derived parathyroid glands with predominating adenoma morphology expressed less P-gp, as compared to P-gp-rich T-HPTH glands, mainly displaying nodular or diffused hyperplasia phenotype. This finding reversely correlated with results of 99mTc-MIBI scintigraphy. However, we did not observe any difference in P-gp expression nor scintigraphy result between nodular or diffused hyperplasia. Altogether, these data suggest that P-gp overexpression in T-HPTH could be responsible for decreased sensitivity of 99mTc-MIBI scintigraphy in those patients. Therefore, the recently proposed reduced neck exploration or limited parathyroid resection on the basis of scintigraphy could create the risk of persisted/recurrent hyperparathyroidism. However, this problem requires further study.

Related Articles

Journal Cover

August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chudzinski W, Niderla J, Lasiecka Z, Wilczynski G, Gornicka B, Wasiutynski A, Maczewska J, Kobylecka M, Krolicki L, Durlik M, Durlik M, et al: P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism. Int J Mol Med 16: 215-219, 2005
APA
Chudzinski, W., Niderla, J., Lasiecka, Z., Wilczynski, G., Gornicka, B., Wasiutynski, A. ... Grzela, T. (2005). P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism. International Journal of Molecular Medicine, 16, 215-219. https://doi.org/10.3892/ijmm.16.2.215
MLA
Chudzinski, W., Niderla, J., Lasiecka, Z., Wilczynski, G., Gornicka, B., Wasiutynski, A., Maczewska, J., Kobylecka, M., Krolicki, L., Durlik, M., Nowacka, E., Lazarczyk, M., Dziunycz, P., Milewski, L., Nawrot, I., Grzela, T."P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism". International Journal of Molecular Medicine 16.2 (2005): 215-219.
Chicago
Chudzinski, W., Niderla, J., Lasiecka, Z., Wilczynski, G., Gornicka, B., Wasiutynski, A., Maczewska, J., Kobylecka, M., Krolicki, L., Durlik, M., Nowacka, E., Lazarczyk, M., Dziunycz, P., Milewski, L., Nawrot, I., Grzela, T."P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism". International Journal of Molecular Medicine 16, no. 2 (2005): 215-219. https://doi.org/10.3892/ijmm.16.2.215