Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells

  • Authors:
    • Hiroshige Hibasami
    • Hiroshi Iwase
    • Kazumi Yoshioka
    • Hidehisa Takahashi
  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/ijmm.16.2.233
  • Pages: 233-236
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Abstract

We have investigated the effects of glycyrrhizin (GL) on cell proliferations of human stomach cancer KATO III and promyelotic leukemia HL-60 cells, and on DNA of those cell lines. GL displayed growth inhibitory effect against KATO III and HL-60 cells. Morphological change showing apoptotic bodies was observed in the KATO III and HL-60 cells treated with GL. The fragmentation of DNA by GL to oligonucleo-somal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in both cell lines. Caspase inhibitors such as Z-VAD-FMK and Z-Asp-CH2-DCB suppressed the DNA fragmentation induced by GL. The data of the present study show that the suppression of KATO III and HL-60 cell-growth by GL results from the induction of apoptosis by GL, and that caspase is involved in the induction of apoptosis by GL in these cells.

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August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hibasami H, Iwase H, Yoshioka K and Takahashi H: Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int J Mol Med 16: 233-236, 2005.
APA
Hibasami, H., Iwase, H., Yoshioka, K., & Takahashi, H. (2005). Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. International Journal of Molecular Medicine, 16, 233-236. https://doi.org/10.3892/ijmm.16.2.233
MLA
Hibasami, H., Iwase, H., Yoshioka, K., Takahashi, H."Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 16.2 (2005): 233-236.
Chicago
Hibasami, H., Iwase, H., Yoshioka, K., Takahashi, H."Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 16, no. 2 (2005): 233-236. https://doi.org/10.3892/ijmm.16.2.233