MMP14 gene polymorphisms in chronic obstructive pulmonary disease

  • Authors:
    • Wataru Saitoh
    • Tohru Sakamoto
    • Ahmed E. Hegab
    • Akihiro Nomura
    • Yukio Ishii
    • Yuko Morishima
    • Sachiko Kai
    • Takashi Iizuka
    • Takumi Kiwamoto
    • Yosuke Matsuno
    • Hosam H. Massoud
    • Hosny M. Massoud
    • Khalid M. Hassanein
    • Kiyohisa Sekizawa
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/ijmm.17.4.621
  • Pages: 621-626
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Abstract

Proteinase/antiproteinase imbalance is a widely accepted theory for the pathogenesis of COPD. Among various proteinases, matrix metalloproteinases (MMPs) digest extracellular matrix of the lung and play significant roles in the development of COPD. Polymorphisms of an MMP that upregulate its activity may result in the degradation of the lung matrix. A case-control study was performed to investigate the association of polymorphisms of the MMP14 gene with COPD. Japanese subjects (96 COPD patients and 61 controls) and Egyptian subjects (106 COPD patients and 72 controls) were recruited. Each subject was genotyped for seven single nucleotide polymorphisms (SNPs) of the MMP14 gene; −165 G/T and −72 G/A in the promoter region, +221 C/T in exon 1, +6727 C/G and +6767 G/A in exon 5, +7096 T/C in exon 6, and +8153 G/A in exon 8. The distributions of the genotype frequencies of these SNPs were not significantly different between the COPD patients and the controls in either ethnic group after correction of multiple comparisons. In the haplotype analysis, however, the haplotype −165 T : +221 T : +6727 C : +7096 C had a significantly higher frequency in the Egyptian COPD group than the control group (pcorr =0.0063). The haplotype of the MMP14 gene, −165 T : +221 T : +6727 C : +7096 C, might be involved in the pathogenesis of COPD.

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April 2006
Volume 17 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Saitoh W, Sakamoto T, Hegab AE, Nomura A, Ishii Y, Morishima Y, Kai S, Iizuka T, Kiwamoto T, Matsuno Y, Matsuno Y, et al: MMP14 gene polymorphisms in chronic obstructive pulmonary disease. Int J Mol Med 17: 621-626, 2006.
APA
Saitoh, W., Sakamoto, T., Hegab, A.E., Nomura, A., Ishii, Y., Morishima, Y. ... Sekizawa, K. (2006). MMP14 gene polymorphisms in chronic obstructive pulmonary disease. International Journal of Molecular Medicine, 17, 621-626. https://doi.org/10.3892/ijmm.17.4.621
MLA
Saitoh, W., Sakamoto, T., Hegab, A. E., Nomura, A., Ishii, Y., Morishima, Y., Kai, S., Iizuka, T., Kiwamoto, T., Matsuno, Y., Massoud, H. H., Massoud, H. M., Hassanein, K. M., Sekizawa, K."MMP14 gene polymorphisms in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 17.4 (2006): 621-626.
Chicago
Saitoh, W., Sakamoto, T., Hegab, A. E., Nomura, A., Ishii, Y., Morishima, Y., Kai, S., Iizuka, T., Kiwamoto, T., Matsuno, Y., Massoud, H. H., Massoud, H. M., Hassanein, K. M., Sekizawa, K."MMP14 gene polymorphisms in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 17, no. 4 (2006): 621-626. https://doi.org/10.3892/ijmm.17.4.621