Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines

  • Authors:
    • Dipali Raha
    • Cinzia Tortorella
    • Giuliano Neri
    • Anita Prasad
    • Bushra Raza
    • Ranu Raskar
    • Rakhi Dubey
    • Nisarga S. Sen
    • Carlo Macchi
    • Ludwick K. Malendowicz
    • M. Firoz Ahmad
    • Gastone G. Nussdorfer
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/ijmm.17.4.633
  • Pages: 633-636
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Abstract

Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed, along with its receptors, in organs and body tissues. ANP is well known to inhibit aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone production is controversial. In vivo experiments showed that prolonged ANP administration raised the plasma concentration of cortisol in both normal and dexamethasone/captopril-treated guinea pigs (i.e. in animals with pharmacologically interrupted hypothalamic-pituitary-adrenal axis and renin-angiotensin system). ANP did not affect cortisol secretion from dispersed guinea pig zona fasciculata-reticularis cells, but enhanced catecholamine release from adrenomedullary cells. ANP stimulated cortisol output from guinea pig adrenal slices containing medullary chromaffin tissue, and the β-adrenoceptor antagonist l-alprenolol blocked this effect. The conclusion is drawn that ANP, when the structural integrity of the adrenal gland is preserved, is able to enhance glucocorticoid secretion in guinea pigs, through an indirect mechanism involving the rise in the catecholamine release, which in turn, acting in a paracrine manner, stimulate secretion of inner adrenocortical cells.

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April 2006
Volume 17 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Raha D, Tortorella C, Neri G, Prasad A, Raza B, Raskar R, Dubey R, Sen NS, Macchi C, Malendowicz LK, Malendowicz LK, et al: Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines. Int J Mol Med 17: 633-636, 2006
APA
Raha, D., Tortorella, C., Neri, G., Prasad, A., Raza, B., Raskar, R. ... Nussdorfer, G.G. (2006). Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines. International Journal of Molecular Medicine, 17, 633-636. https://doi.org/10.3892/ijmm.17.4.633
MLA
Raha, D., Tortorella, C., Neri, G., Prasad, A., Raza, B., Raskar, R., Dubey, R., Sen, N. S., Macchi, C., Malendowicz, L. K., Ahmad, M. F., Nussdorfer, G. G."Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines". International Journal of Molecular Medicine 17.4 (2006): 633-636.
Chicago
Raha, D., Tortorella, C., Neri, G., Prasad, A., Raza, B., Raskar, R., Dubey, R., Sen, N. S., Macchi, C., Malendowicz, L. K., Ahmad, M. F., Nussdorfer, G. G."Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines". International Journal of Molecular Medicine 17, no. 4 (2006): 633-636. https://doi.org/10.3892/ijmm.17.4.633