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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2006 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes

  • Authors:
    • Jürgen Radons
    • Anja Katrin Bosserhoff
    • Susanne Grässel
    • Werner Falk
    • Thomas E.O. Schubert

  • View Affiliations / Copyright

    Affiliations: Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Regensburg, D-93053 Regensburg, Germany. juergen.radons@klinik.uni-regensburg.de
  • Pages: 661-668
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/ijmm.17.4.661
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Abstract

The pleiotropic cytokine interleukin 1 (IL-1) is considered to be the principal inducer of mediators of cartilage degradation in both, osteoarthritis (OA) and rheumatoid arthritis (RA). IL-1 activates numerous signaling pathways involved in cartilage destruction and dedifferentiation of chondrocytes. In this study, we analyzed expression and functional effects of IL-1 in human chondrocytes. We found an IL-1-induced reduction in the expression of the cartilage specific proteoglycan aggrecan as an indicator for the IL-1-mediated dedifferentiation of chondrocytes. To block the IL-1-induced signaling pathways specifically, we incubated human chondrocytes and cartilage explants with IL-1 in the presence of different signal transduction inhibitors and analyzed their effect on aggrecan mRNA expression and IL-6 secretion. IL-6 has been found to act synergistically in the IL-1-induced suppression of the proteoglycan synthesis in chondrocytes. Our results led to the identification of p38MAPK and/or PI3K/JNK as being crucial for IL-1-induced IL-6 secretion by chondrocytes. IL-1-induced down-regulation of aggrecan expression was found to be mediated by p38MAPK and/or ERK1/2. The identification and characterization of these signaling pathways will enable us to develop new modulation strategies for therapeutic use in inflammatory joint diseases.

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Copy and paste a formatted citation
Spandidos Publications style
Radons J, Bosserhoff AK, Grässel S, Falk W and Schubert TE: p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med 17: 661-668, 2006.
APA
Radons, J., Bosserhoff, A.K., Grässel, S., Falk, W., & Schubert, T.E. (2006). p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. International Journal of Molecular Medicine, 17, 661-668. https://doi.org/10.3892/ijmm.17.4.661
MLA
Radons, J., Bosserhoff, A. K., Grässel, S., Falk, W., Schubert, T. E."p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes". International Journal of Molecular Medicine 17.4 (2006): 661-668.
Chicago
Radons, J., Bosserhoff, A. K., Grässel, S., Falk, W., Schubert, T. E."p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes". International Journal of Molecular Medicine 17, no. 4 (2006): 661-668. https://doi.org/10.3892/ijmm.17.4.661
Copy and paste a formatted citation
x
Spandidos Publications style
Radons J, Bosserhoff AK, Grässel S, Falk W and Schubert TE: p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med 17: 661-668, 2006.
APA
Radons, J., Bosserhoff, A.K., Grässel, S., Falk, W., & Schubert, T.E. (2006). p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. International Journal of Molecular Medicine, 17, 661-668. https://doi.org/10.3892/ijmm.17.4.661
MLA
Radons, J., Bosserhoff, A. K., Grässel, S., Falk, W., Schubert, T. E."p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes". International Journal of Molecular Medicine 17.4 (2006): 661-668.
Chicago
Radons, J., Bosserhoff, A. K., Grässel, S., Falk, W., Schubert, T. E."p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes". International Journal of Molecular Medicine 17, no. 4 (2006): 661-668. https://doi.org/10.3892/ijmm.17.4.661
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