Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus

  • Authors:
    • Takahiko Horiuchi
    • Chika Morita
    • Hiroshi Tsukamoto
    • Hiroki Mitoma
    • Takuya Sawabe
    • Shin-Ichi Harashima
    • Yoichiro Kashiwagi
    • Seiichi Okamura
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijmm.17.5.875
  • Pages: 875-879
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Membrane TNF-α is a precursor form of soluble TNF-α and exerts pro-inflammatory functions in a cell-to-cell contact manner. We showed that membrane TNF-α is induced upon activation on the cell surface of CD4+ T cells and CD8+ T cells. In patients with systemic lupus erythematosus (SLE), the percentage of membrane TNF-α-bearing CD8+ T cells (41.5±12.3%) was significantly higher compared with those of healthy controls (26.7±3.9%) (p=0.007) or patients with rheumatoid arthritis (29.8±15.4%) (p=0.038). Membrane TNF-α-bearing CD8+ T cells from SLE patients displayed cytotoxic activity against L929 cells. It is possible that membrane TNF-α may be involved in the increased apoptosis and the generation of autoantigens in SLE.

Related Articles

Journal Cover

May 2006
Volume 17 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Horiuchi T, Morita C, Tsukamoto H, Mitoma H, Sawabe T, Harashima S, Kashiwagi Y and Okamura S: Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus. Int J Mol Med 17: 875-879, 2006
APA
Horiuchi, T., Morita, C., Tsukamoto, H., Mitoma, H., Sawabe, T., Harashima, S. ... Okamura, S. (2006). Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus. International Journal of Molecular Medicine, 17, 875-879. https://doi.org/10.3892/ijmm.17.5.875
MLA
Horiuchi, T., Morita, C., Tsukamoto, H., Mitoma, H., Sawabe, T., Harashima, S., Kashiwagi, Y., Okamura, S."Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus". International Journal of Molecular Medicine 17.5 (2006): 875-879.
Chicago
Horiuchi, T., Morita, C., Tsukamoto, H., Mitoma, H., Sawabe, T., Harashima, S., Kashiwagi, Y., Okamura, S."Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus". International Journal of Molecular Medicine 17, no. 5 (2006): 875-879. https://doi.org/10.3892/ijmm.17.5.875