Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB

  • Authors:
    • Jungsug Gwak
    • Seoyoung Park
    • Munju Cho
    • Taeyun Song
    • Seon-Heui Cha
    • Dong-Eun Kim
    • You-Jin Jeon
    • Jae-Gook Shin
    • Sangtaek Oh
  • View Affiliations

  • Published online on: June 1, 2006     https://doi.org/10.3892/ijmm.17.6.1005
  • Pages: 1005-1010
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Abstract

Abnormal activation of the Wnt/β-catenin pathway and subsequent up-regulation of β-catenin response transcription (CRT) are associated with the development of colon cancer. Thus, the Wnt/β-catenin pathway is an attractive target for chemoprevention and treatment of this cancer. We used a cell-based screen to identify a methanol extract of Polysiphonia japonica (EPJ) that suppresses the Wnt/β-catenin pathway without altering the level of β-catenin protein and reduces the expression of cyclin D1, which is a known β-catenin/T cell factor (TCF)-dependent gene. EPJ inhibited the growth of various colon cancer cells. In addition, EPJ induced the nuclear translocation of nuclear factor-κB (NF-κB) in SW480 colon cancer cells. Our findings suggest that EPJ attenuates Wnt/β-catenin signaling via activation of NF-κB and can potentially be used as a chemopreventive agent against colon cancer.

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June 2006
Volume 17 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Gwak J, Park S, Cho M, Song T, Cha S, Kim D, Jeon Y, Shin J and Oh S: Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB. Int J Mol Med 17: 1005-1010, 2006.
APA
Gwak, J., Park, S., Cho, M., Song, T., Cha, S., Kim, D. ... Oh, S. (2006). Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB. International Journal of Molecular Medicine, 17, 1005-1010. https://doi.org/10.3892/ijmm.17.6.1005
MLA
Gwak, J., Park, S., Cho, M., Song, T., Cha, S., Kim, D., Jeon, Y., Shin, J., Oh, S."Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB". International Journal of Molecular Medicine 17.6 (2006): 1005-1010.
Chicago
Gwak, J., Park, S., Cho, M., Song, T., Cha, S., Kim, D., Jeon, Y., Shin, J., Oh, S."Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB". International Journal of Molecular Medicine 17, no. 6 (2006): 1005-1010. https://doi.org/10.3892/ijmm.17.6.1005