Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes

  • Authors:
    • Takahiro Kawamoto
    • Kiyonori Togi
    • Ryoko Yamauchi
    • Yoshinori Yoshida
    • Yasuhiro Nakashima
    • Toru Kita
    • Makoto Tanaka
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/ijmm.18.1.193
  • Pages: 193-196
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Homer proteins are a family of scaffolding proteins which may play an important role in calcium signaling by facilitating the assembly of signaling complexes in neuronal cells. Among the three splice variants of Homer 1, Homer 1α is rapidly up-regulated by neural stimulation and may regulate the disassembly of signaling complexes mediated by Homer proteins. In spite of its potential importance in calcium signaling, the regulation of Homer 1α expression in cardiac myocytes has never been investigated. In this study, we examined the regulation of Homer 1α expression in cardiac myocytes. Homer 1α was significantly up-regulated by several hypertrophic agonists, including endothelin-1 (ET-1), phenyl-ephrine, isoprotenerol and angiotensin-II, and ET-1 most strikingly induced Homer 1α expression. The induction of Homer 1α expression by ET-1 peaked at 2 h and inhibitors for mitogen-activated/extracellular signal regulated kinase (MEK) significantly suppressed the induction of Homer 1α. This study first clarified the regulation of Homer 1α expression in cardiac myocytes and demonstrated that ET-1 induced Homer 1α expression through the mitogen-activated protein kinase pathway.

Related Articles

Journal Cover

July 2006
Volume 18 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kawamoto T, Togi K, Yamauchi R, Yoshida Y, Nakashima Y, Kita T and Tanaka M: Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. Int J Mol Med 18: 193-196, 2006
APA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., & Tanaka, M. (2006). Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. International Journal of Molecular Medicine, 18, 193-196. https://doi.org/10.3892/ijmm.18.1.193
MLA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18.1 (2006): 193-196.
Chicago
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18, no. 1 (2006): 193-196. https://doi.org/10.3892/ijmm.18.1.193