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Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods

  • Authors:
    • Niels Halama
    • Silke A. Grauling-Halama
    • Dirk Jäger Shimizu

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  • Published online on: October 1, 2006     https://doi.org/10.3892/ijmm.18.4.653
  • Pages: 653-656
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Abstract

StAR (steroidogenic acute regulatory) proteins and proteins with StAR-related lipid transfer (START) domains are involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. In this present study we characterized the StARD9 gene by bioinformatical methods. The human StARD9 gene (syn. KIAA1300), consisting of 11 exons, was located within human genome sequence CTD-2036P10 (AC090510). The complete coding sequence of human StARD9 cDNA was determined by DKFZp781J069 cDNA (CR749416), which was identified by using a partial coding sequence of human StARD9 cDNA (AB037721) as a query. The existing predicted gene model could be refined based on EST-analysis. Comparison of the human protein sequence with chimpanzee, rat, mouse and chicken homologs showed a 98% (chimpanzee), 60% (rat), 60% (mouse) and 45% (chicken) amino-acid identity respectively. A lipid-binding START domain was identified within StARD9 protein. This is the first report on characterization of the StARD9 gene.

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October 2006
Volume 18 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Halama N, Grauling-Halama SA and Shimizu D: Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. Int J Mol Med 18: 653-656, 2006
APA
Halama, N., Grauling-Halama, S.A., & Shimizu, D. (2006). Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. International Journal of Molecular Medicine, 18, 653-656. https://doi.org/10.3892/ijmm.18.4.653
MLA
Halama, N., Grauling-Halama, S. A., Shimizu, D."Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods". International Journal of Molecular Medicine 18.4 (2006): 653-656.
Chicago
Halama, N., Grauling-Halama, S. A., Shimizu, D."Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods". International Journal of Molecular Medicine 18, no. 4 (2006): 653-656. https://doi.org/10.3892/ijmm.18.4.653