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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2006 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 18 Issue 5

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Article

Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice

  • Authors:
    • Dai Takagi
    • Kazuya Iwabuchi
    • Masanori Maeda
    • Yuji Nakamaru
    • Yasushi Furuta
    • Satoshi Fukuda
    • Luc Van Kaer
    • Jun Nishihira
    • Kazunori Onoé

  • View Affiliations / Copyright

    Affiliations: Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
  • Pages: 829-836
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/ijmm.18.5.829
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Abstract

Macrophage migration inhibitory factor (MIF) plays an important role in inflammatory diseases. It has been reported that anti-MIF treatment and mif-gene disruption ameliorate joint inflammation in a mouse model of arthritis induced by anti-type II collagen monoclonal antibodies and lipopolysaccharide (anti-IIC mAb/LPS). In the present study, using the anti-IIC mAb/LPS system, we have analyzed arthritis in MIF-transgenic (MIFTg) and wild-type C57BL/6 (WT) mice. We found that MIFTg mice developed more severe arthritis than WT mice. The histopathological scores were significantly higher in MIFTg mice and significantly increased numbers of CD69+ T cells were detected in the spleens of these arthritic MIFTg mice, compared with WT mice. Natural killer T (NKT) cells from MIFTg mice, compared with WT mice, produced reduced amounts of IL-4 upon stimulation with agr;-galactosylceramide (α-GalCer). Further, repeated administration of α-GalCer to MIFTg mice resulted in a profound reduction of both clinical and histopathological scores of arthritis, with a significant decrease in IL-6. The present findings demonstrate that overexpression of MIF exacerbates inflammation in this arthritis model and that NKT cells play an ameliorating role upon stimulation with α-GalCer in the inflammatory process in MIFTg mice.

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Copy and paste a formatted citation
Spandidos Publications style
Takagi D, Iwabuchi K, Maeda M, Nakamaru Y, Furuta Y, Fukuda S, Van Kaer L, Nishihira J and Onoé K: Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int J Mol Med 18: 829-836, 2006.
APA
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S. ... Onoé, K. (2006). Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. International Journal of Molecular Medicine, 18, 829-836. https://doi.org/10.3892/ijmm.18.5.829
MLA
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S., Van Kaer, L., Nishihira, J., Onoé, K."Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice". International Journal of Molecular Medicine 18.5 (2006): 829-836.
Chicago
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S., Van Kaer, L., Nishihira, J., Onoé, K."Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice". International Journal of Molecular Medicine 18, no. 5 (2006): 829-836. https://doi.org/10.3892/ijmm.18.5.829
Copy and paste a formatted citation
x
Spandidos Publications style
Takagi D, Iwabuchi K, Maeda M, Nakamaru Y, Furuta Y, Fukuda S, Van Kaer L, Nishihira J and Onoé K: Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int J Mol Med 18: 829-836, 2006.
APA
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S. ... Onoé, K. (2006). Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. International Journal of Molecular Medicine, 18, 829-836. https://doi.org/10.3892/ijmm.18.5.829
MLA
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S., Van Kaer, L., Nishihira, J., Onoé, K."Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice". International Journal of Molecular Medicine 18.5 (2006): 829-836.
Chicago
Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S., Van Kaer, L., Nishihira, J., Onoé, K."Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice". International Journal of Molecular Medicine 18, no. 5 (2006): 829-836. https://doi.org/10.3892/ijmm.18.5.829
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