Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra

  • Authors:
    • Vitaliano Tugnoli
    • Luisa Schenetti
    • Adele Mucci
    • Francesca Parenti
    • Rita Cagnoli
    • Valeria Righi
    • Andrea Trinchero
    • Luca Nocetti
    • Cristian Toraci
    • Luciano Mavilla
    • Gianpaolo Trentini
    • Elena Zunarelli
    • M. Raffaella Tosi
  • View Affiliations

  • Published online on: November 1, 2006     https://doi.org/10.3892/ijmm.18.5.859
  • Pages: 859-869
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Abstract

We report on the magnetic resonance spectroscopy (MRS) characterisation of different human meningiomas. Three histological subtypes of meningiomas (meningothelial, fibrous and oncocytic) were analysed both through in vivo and ex vivo MRS experiments. The ex vivo high-resolution magic angle spinning (HR-MAS) investigations, permitting an accurate description of the metabolic profile, are very helpful for the assignment of the resonances in vivo of human meningiomas and for the validation of the quantification procedure of in vivo MR spectra. By using one- and two-dimensional experiments, we were able to identify several metabolites in different histological subtypes of meningiomas. Our spectroscopic data confirmed the presence of the typical metabolites of these benign neoplasms and, at the same time, that meningomas with different morphological characteristics have different metabolic profiles, particularly regarding macromolecules and lipids. The ex vivo spectra allowed a better understanding and interpretation of the in vivo MR spectra, showing that the HR-MAS MRS technique could be a complementary method to strongly support the in vivo MR spectroscopy and increase its clinical potentiality.

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November 2006
Volume 18 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tugnoli V, Schenetti L, Mucci A, Parenti F, Cagnoli R, Righi V, Trinchero A, Nocetti L, Toraci C, Mavilla L, Mavilla L, et al: Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra. Int J Mol Med 18: 859-869, 2006.
APA
Tugnoli, V., Schenetti, L., Mucci, A., Parenti, F., Cagnoli, R., Righi, V. ... Tosi, M.R. (2006). Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra. International Journal of Molecular Medicine, 18, 859-869. https://doi.org/10.3892/ijmm.18.5.859
MLA
Tugnoli, V., Schenetti, L., Mucci, A., Parenti, F., Cagnoli, R., Righi, V., Trinchero, A., Nocetti, L., Toraci, C., Mavilla, L., Trentini, G., Zunarelli, E., Tosi, M. R."Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra". International Journal of Molecular Medicine 18.5 (2006): 859-869.
Chicago
Tugnoli, V., Schenetti, L., Mucci, A., Parenti, F., Cagnoli, R., Righi, V., Trinchero, A., Nocetti, L., Toraci, C., Mavilla, L., Trentini, G., Zunarelli, E., Tosi, M. R."Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra". International Journal of Molecular Medicine 18, no. 5 (2006): 859-869. https://doi.org/10.3892/ijmm.18.5.859