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Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review)

  • Authors:
    • Enrico Crivellato
    • Beatrice Nico
    • Eugenio Bertelli
    • Gastone G. Nussdorfer
    • Domenico Ribatti

  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijmm.18.6.1037
  • Pages: 1037-1046
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Abstract

The term piecemeal degranulation (PMD) refers to a slow releasing process mediated by vesicular transport of stored secretory granule contents. This form of cell secretion was first proposed for basophils, mast cells and eosinophils, but evidence has begun to accumulate that PMD also occurs in dense-core granules of neuroendocrine cells and neurons. This review summarizes the electron-microscopic evidence that has been gathered in support of this view and also discusses the possible physiological significance of PMD in this class of secretory organelles in comparison with ‘full fusion’ and ‘kiss-and-run’ exocytosis.

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Journal Cover

December 2006
Volume 18 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Crivellato E, Nico B, Bertelli E, Nussdorfer GG and Ribatti D: Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review). Int J Mol Med 18: 1037-1046, 2006
APA
Crivellato, E., Nico, B., Bertelli, E., Nussdorfer, G.G., & Ribatti, D. (2006). Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review). International Journal of Molecular Medicine, 18, 1037-1046. https://doi.org/10.3892/ijmm.18.6.1037
MLA
Crivellato, E., Nico, B., Bertelli, E., Nussdorfer, G. G., Ribatti, D."Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review)". International Journal of Molecular Medicine 18.6 (2006): 1037-1046.
Chicago
Crivellato, E., Nico, B., Bertelli, E., Nussdorfer, G. G., Ribatti, D."Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review)". International Journal of Molecular Medicine 18, no. 6 (2006): 1037-1046. https://doi.org/10.3892/ijmm.18.6.1037