search button

Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice

  • Authors:
    • Shengjun Wang
    • Huaxi Xu
    • Yongzhong Wang
    • Jie Ma
    • Chaoming Mao
    • Qixiang Shao
    • Bin Ma
    • Wenrong Xu
    • Shengli Yang

  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijmm.18.6.1193
  • Pages: 1193-1199
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

CD4+CD25+ regulatory T (Treg) cells are immunosuppressive and help maintain peripheral immune tolerance. The forkhead/winged helix family member, Foxp3, has been shown to be a critical regulator of CD4+CD25+ Treg cells. We demonstrate by quantitative real-time PCR that CD4+CD25+ T cells express higher levels of Foxp3 mRNA than other T cell populations. Recombinant adeno-associated virus vector carrying mouse Foxp3 gene under the control of the CMV promoter was generated and used to transduce CD4+CD25− T cells. These Foxp3-transduced T cells are similar to naturally occurring CD4+CD25+ regulatory T cells which show anergy and immunosuppressive activity in vitro. Furthermore, these Foxp3-transduced T cells prevent autoimmune thyroiditis transferred by pathogenic T cells in vivo. Our data indicates that Foxp3-transduced CD4+CD25− T cells may open new therapeutic strategies for immune disorders.

Related Articles

Journal Cover

December 2006
Volume 18 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Xu H, Wang Y, Ma J, Mao C, Shao Q, Ma B, Xu W and Yang S: Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. Int J Mol Med 18: 1193-1199, 2006
APA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q. ... Yang, S. (2006). Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 18, 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
MLA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18.6 (2006): 1193-1199.
Chicago
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18, no. 6 (2006): 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193