Bone metastasis in prostate cancer: Molecular and cellular mechanisms (Review)

  • Authors:
    • Lin Ye
    • Howard G. Kynaston
    • Wen G. Jiang
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/ijmm.20.1.103
  • Pages: 103-111
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. The bony metastasis is incurable and contributes significantly to disease-specific morbidity and mortality. The molecular and cellular mechanisms leading to the development of bone metastasis in prostate cancer remain unclear, but are currently under intensive investigation. In this review, we summarized the current understanding of bone metastasis in prostate cancer. The rapid progress in the genetic predisposition that makes prostate cancer cells more prone to spread to bone, bone-derived factors which are involved in the development of bone metastasis at the level of the local microenvironment, the interactions between metastatic prostate cancer cells and bone marrow endothelial cells, osteoblasts, and osteoclasts, are discussed in this article.

Related Articles

Journal Cover

July 2007
Volume 20 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ye, L., Kynaston, H.G., & Jiang, W.G. (2007). Bone metastasis in prostate cancer: Molecular and cellular mechanisms (Review). International Journal of Molecular Medicine, 20, 103-111. https://doi.org/10.3892/ijmm.20.1.103
MLA
Ye, L., Kynaston, H. G., Jiang, W. G."Bone metastasis in prostate cancer: Molecular and cellular mechanisms (Review)". International Journal of Molecular Medicine 20.1 (2007): 103-111.
Chicago
Ye, L., Kynaston, H. G., Jiang, W. G."Bone metastasis in prostate cancer: Molecular and cellular mechanisms (Review)". International Journal of Molecular Medicine 20, no. 1 (2007): 103-111. https://doi.org/10.3892/ijmm.20.1.103