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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2008 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 21 Issue 2

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Article

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn

  • Authors:
    • A. Aria Tzika
    • Dionyssios Mintzopoulos
    • Katie Padfield
    • julie wilhelmy
    • Michael N. Mindrinos
    • Hongue Yu
    • Haihui Cao
    • Qunhao Zhang
    • Loukas G. Astrakas
    • Jiangwen Zhang
    • Yong-Ming Yu
    • Laurence G. Rahme
    • Ronald G. Tompkins
  • View Affiliations / Copyright

    Affiliations: NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. atzika@partners.org
  • Pages: 201-208
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/ijmm.21.2.201
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Abstract

Using a mouse model of burn trauma, we tested the hypothesis that severe burn trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to assess the rate of ATP synthesis, and characterized the concomitant gene expression patterns in skeletal muscle in burned (30% TBSA) versus control mice. Our NMR results showed a significantly reduced rate of ATP synthesis and were complemented by genomic results showing downregulation of the ATP synthase mitochondrial F1F0 complex and PGC-1β gene expression. Our findings suggest that inflammation and muscle atrophy in burns are due to a reduced ATP synthesis rate that may be regulated upstream by PGC-1β. These findings implicate mitochondrial dysfunction in distal skeletal muscle following burn injury. That PGC-1β is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1β.

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Copy and paste a formatted citation
Spandidos Publications style
Tzika AA, Mintzopoulos D, Padfield K, wilhelmy j, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Zhang J, et al: Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn. Int J Mol Med 21: 201-208, 2008.
APA
Tzika, A.A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M.N., Yu, H. ... Tompkins, R.G. (2008). Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn. International Journal of Molecular Medicine, 21, 201-208. https://doi.org/10.3892/ijmm.21.2.201
MLA
Tzika, A. A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M. N., Yu, H., Cao, H., Zhang, Q., Astrakas, L. G., Zhang, J., Yu, Y., Rahme, L. G., Tompkins, R. G."Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn". International Journal of Molecular Medicine 21.2 (2008): 201-208.
Chicago
Tzika, A. A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M. N., Yu, H., Cao, H., Zhang, Q., Astrakas, L. G., Zhang, J., Yu, Y., Rahme, L. G., Tompkins, R. G."Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn". International Journal of Molecular Medicine 21, no. 2 (2008): 201-208. https://doi.org/10.3892/ijmm.21.2.201
Copy and paste a formatted citation
x
Spandidos Publications style
Tzika AA, Mintzopoulos D, Padfield K, wilhelmy j, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Zhang J, et al: Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn. Int J Mol Med 21: 201-208, 2008.
APA
Tzika, A.A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M.N., Yu, H. ... Tompkins, R.G. (2008). Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn. International Journal of Molecular Medicine, 21, 201-208. https://doi.org/10.3892/ijmm.21.2.201
MLA
Tzika, A. A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M. N., Yu, H., Cao, H., Zhang, Q., Astrakas, L. G., Zhang, J., Yu, Y., Rahme, L. G., Tompkins, R. G."Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn". International Journal of Molecular Medicine 21.2 (2008): 201-208.
Chicago
Tzika, A. A., Mintzopoulos, D., Padfield, K., wilhelmy, j., Mindrinos, M. N., Yu, H., Cao, H., Zhang, Q., Astrakas, L. G., Zhang, J., Yu, Y., Rahme, L. G., Tompkins, R. G."Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn". International Journal of Molecular Medicine 21, no. 2 (2008): 201-208. https://doi.org/10.3892/ijmm.21.2.201
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