The longevity assurance homologue of yeast lag1 (Lass) gene family (Review)

  • Authors:
    • Andreas Teufel
    • Thorsten Maass
    • Peter R. Galle
    • Nasir Malik
  • View Affiliations

  • Published online on: February 1, 2009     https://doi.org/10.3892/ijmm_00000110
  • Pages: 135-140
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Abstract

The Lass gene family contains a group of highly conserved genes that are found in eukaryotic species. The founding member, lag1, was discovered in a screen for yeast longevity genes. Subsequently, lag1 homologs were discovered in other organisms including six mammalian paralogs. All Lass genes encode a highly conserved Lag1 domain and many also have an additional Hox domain. Lass proteins are ceramide synthases and therefore are critical for ceramide biosynthesis. Ceramide synthase is also a critical enzyme in the sphingolipid biosynthetic pathway. As ceramide and sphingolipids are key intermediates in diverse cellular processes such as cell growth, apoptosis, and stress response and may also play a role in cancer development, the function of Lass proteins is of great interest. In this review, we summarize the state of knowledge regarding Lass protein structure, biological function, and their emerging role in cancer development.

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February 2009
Volume 23 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Teufel, A., Maass, T., Galle, P.R., & Malik, N. (2009). The longevity assurance homologue of yeast lag1 (Lass) gene family (Review). International Journal of Molecular Medicine, 23, 135-140. https://doi.org/10.3892/ijmm_00000110
MLA
Teufel, A., Maass, T., Galle, P. R., Malik, N."The longevity assurance homologue of yeast lag1 (Lass) gene family (Review)". International Journal of Molecular Medicine 23.2 (2009): 135-140.
Chicago
Teufel, A., Maass, T., Galle, P. R., Malik, N."The longevity assurance homologue of yeast lag1 (Lass) gene family (Review)". International Journal of Molecular Medicine 23, no. 2 (2009): 135-140. https://doi.org/10.3892/ijmm_00000110