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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2010 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 26 Issue 2

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Article

The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro

  • Authors:
    • Bo Li
    • Xiang Li
    • Yingxin Li
    • Hui Guo
    • Shu-Yan Sun
    • Qiong-Qiong He
    • Ying Wang
    • Junming Luo
    • Ji-Fang Wen
    • Hui Zheng
    • De-Yun Feng

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410013, P.R. China
  • Pages: 273-279
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/ijmm_00000462
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Abstract

Hepatitis C virus (HCV) infection has become a severe health problem worldwide. The viral proteins are believed to be among the most important factors that contribute to HCV mediated pathogenesis. Accumulated evidence demonstrating that HCV non-structural protein 3 (NS3) possesses oncogenic potential, and is involved in the regulation of cell proliferation has been documented. In this study, we emphasized the effect of HCV NS3 protein on cell proliferation in the immortally normal hepatocyte QSG7701 cells. The cell line transfected with plasmid expressing NS3 protein showed enhanced cell growth, extracellular signal-related kinase (ERK) activation, DNA binding activities of transcription factors of activator protein 1 (AP-1) and NF-κB, and cyclin D1 overexpression, but without activation of Jun amino-terminal kinase or p38. Pre-treatment of NS3 protein expressing cells with ERK inhibitor, PD98059, blocked the activation of AP-1 and NF-κB, and inhibited cyclin D1 expression and cell proliferation. The results suggest that NS3-mediated cell growth occurs through activation of ERK/AP-1 and NF-κB/cyclin D1 cascades.

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Copy and paste a formatted citation
Spandidos Publications style
Li B, Li X, Li Y, Guo H, Sun S, He Q, Wang Y, Luo J, Wen J, Zheng H, Zheng H, et al: The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro. Int J Mol Med 26: 273-279, 2010.
APA
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q. ... Feng, D. (2010). The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro. International Journal of Molecular Medicine, 26, 273-279. https://doi.org/10.3892/ijmm_00000462
MLA
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q., Wang, Y., Luo, J., Wen, J., Zheng, H., Feng, D."The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro". International Journal of Molecular Medicine 26.2 (2010): 273-279.
Chicago
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q., Wang, Y., Luo, J., Wen, J., Zheng, H., Feng, D."The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro". International Journal of Molecular Medicine 26, no. 2 (2010): 273-279. https://doi.org/10.3892/ijmm_00000462
Copy and paste a formatted citation
x
Spandidos Publications style
Li B, Li X, Li Y, Guo H, Sun S, He Q, Wang Y, Luo J, Wen J, Zheng H, Zheng H, et al: The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro. Int J Mol Med 26: 273-279, 2010.
APA
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q. ... Feng, D. (2010). The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro. International Journal of Molecular Medicine, 26, 273-279. https://doi.org/10.3892/ijmm_00000462
MLA
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q., Wang, Y., Luo, J., Wen, J., Zheng, H., Feng, D."The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro". International Journal of Molecular Medicine 26.2 (2010): 273-279.
Chicago
Li, B., Li, X., Li, Y., Guo, H., Sun, S., He, Q., Wang, Y., Luo, J., Wen, J., Zheng, H., Feng, D."The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro". International Journal of Molecular Medicine 26, no. 2 (2010): 273-279. https://doi.org/10.3892/ijmm_00000462
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