search button

The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach

  • Authors:
    • Magdalena Cañete
    • Jorge Soriano
    • Angeles Villanueva
    • Alejandro G. Roca
    • Sabino Veintemillas
    • Carlos J. Serna
    • Rodolfo Miranda
    • Maria Del Puerto Morales

  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/ijmm_00000496
  • Pages: 533-539
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In this study we present a morphological approach in observing the interaction of cationic magnetic nanoparticles with A-549 cells (human lung adenocarcinoma). Under our experimental conditions, nanoparticles easily penetrated cells and were observed in vivo, using bright light microscopy. In fixed cells, nanoparticles remained inside cells, showing quantity and distribution patterns similar to those in unfixed cells. The presence of nanoparticles did not affect cell viability or the morphologic parameters assessed. We determined the potential internalization mechanism of nanoparticles into cells using endocytosis inhibitors. The results suggest that nanoparticles used in this study penetrate A-549 cells mainly through a macropinocytosis process.

Related Articles

Journal Cover

October 2010
Volume 26 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Cañete M, Soriano J, Villanueva A, Roca AG, Veintemillas S, Serna CJ, Miranda R and Del Puerto Morales M: The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach . Int J Mol Med 26: 533-539, 2010
APA
Cañete, M., Soriano, J., Villanueva, A., Roca, A.G., Veintemillas, S., Serna, C.J. ... Del Puerto Morales, M. (2010). The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach . International Journal of Molecular Medicine, 26, 533-539. https://doi.org/10.3892/ijmm_00000496
MLA
Cañete, M., Soriano, J., Villanueva, A., Roca, A. G., Veintemillas, S., Serna, C. J., Miranda, R., Del Puerto Morales, M."The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach ". International Journal of Molecular Medicine 26.4 (2010): 533-539.
Chicago
Cañete, M., Soriano, J., Villanueva, A., Roca, A. G., Veintemillas, S., Serna, C. J., Miranda, R., Del Puerto Morales, M."The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach ". International Journal of Molecular Medicine 26, no. 4 (2010): 533-539. https://doi.org/10.3892/ijmm_00000496