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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2010 Volume 26 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors

Sheng Biao Wan, Huanjie Yang, Zhongyuan Zhou, Qiuzhi Cindy Cui, Di Chen, Jyoti Kanwar, Imthiyaz Mohammad, O. Ping Dou, Tak Hang Chan
Pages: 447-455
Published online on: 01 October 2010

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Article

Biological effects of inorganic arsenic on primary cultures of rat astrocytes

Irene Catanzaro, Gabriella Schiera, Giulia Sciandrello, Giusi Barbata, Fabio Caradonna, Patrizia Proia, Italia Di Liegro
Pages: 457-462
Published online on: 01 October 2010

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Article

UVB radiation induces an increase in intracellular zinc in human epidermal keratinocytes

Christian J. Stork, Lisa M. Martorano, Yang V. Li
Pages: 463-469
Published online on: 01 October 2010

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Article

Oxidative stress parameters in paediatric non-alcoholic fatty liver disease

Valerio Nobili, Maurizio Parola, Anna Alisi, Fabio Marra, Fiorella Piemonte, Christina Mombello, Salvatore Sutti, Davide Povero, Virginia Maina, Erica Novo, Emanuele Albano
Pages: 471-476
Published online on: 01 October 2010

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Article

Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan

Hironori Nakagami, Mariana Kiomy Osako, Futoshi Nakagami, Takashi Shimosato, Noriko Minobe, Toshinori Moritani, Munehisa Shimamura, Takashi Miyake, Hideo Shimizu, Yasushi Takeya, Ryuichi Morishita
Pages: 477-481
Published online on: 01 October 2010

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Article

Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells

Lianxi Li, Xuehong Dong, Man Cheong Leong, Wenbai Zhou, Zhihong Yang, Fengling Chen, Yuqian Bao, Weiping Jia, Renming Hu
Pages: 483-490
Published online on: 01 October 2010

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Article

Synthesis and characterization of a novel cationic polymer gene delivery vector

Song-Lin Shi, Bing Dan, Fan Liu, Li-Rong Lin, Zuo-Gen Fu, Guang-Jun Jing, Tian-Ci Yang, Zhong-Ying Zhang
Pages: 491-500
Published online on: 01 October 2010

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Article

Systemic or topical application of plasminogen activator inhibitor with extended half-life (VLHL PAI-1) reduces bleeding time and total blood loss

Jerzy Jankun, Rick Keck, Steven H. Selman, Ewa Skrzypczak-Jankun
Pages: 501-504
Published online on: 01 October 2010

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Article

Expression and localization of prominin-1 in isoproterenol-treated rat parotid gland

Fabio D'Amico, Evangelia Skarmoutsou, Katia Mangano, Grazia Malaponte, Franca Stivala, Maria Clorinda Mazzarino
Pages: 505-510
Published online on: 01 October 2010

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Article

Fever temperature enhances mechanisms of survival of Streptococcus agalactiae within human endothelial cells

Viviane Oliveira Freitas Lione, Michelle Hanthequeste Bittencourt dos Santos, Técia Maria Ulisses Carvalho, Raphael Hirata, Ana Luiza Mattos-Guaraldi, Renato Arruda Mortara, Prescilla Emy Nagao
Pages: 511-516
Published online on: 01 October 2010

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Article

Repair of orbital wall defects using biocoral scaffolds combined with bone marrow stem cells enhanced by human bone morphogenetic protein-2 in a canine model

Caiwen Xiao, Huifang Zhou, Shengfang Ge, Tingting Tang, Hongliang Hou, Min Luo, Xianqun Fan
Pages: 517-525
Published online on: 01 October 2010

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Article

Enhancement of phagocytotic activity by prion protein in PrP-deficient macrophage cells

Ryuta Uraki, Akikazu Sakudo, Saeko Ando, Hiroshi Kitani, Takashi Onodera
Pages: 527-532
Published online on: 01 October 2010

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Article

The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: A morphological approach

Magdalena Cañete, Jorge Soriano, Angeles Villanueva, Alejandro G. Roca, Sabino Veintemillas, Carlos J. Serna, Rodolfo Miranda, Maria Del Puerto Morales
Pages: 533-539
Published online on: 01 October 2010

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Article

The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats

Yu-Fei Gao, Xiao-Duo Zhu, Dong-Mei Shi, Zhi-Cheng Jing, Li Li, Dan Ma, Zhi-Xin Fan, Jian Li, Yi-Wei Wang, Bing-Xiang Wu
Pages: 541-547
Published online on: 01 October 2010

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Article

Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro

En Mu, Xiujuan Liu, Song Chen, Linlin Zhi, Xin Li, Xianghua Xu, Xiaochun Ma
Pages: 549-555
Published online on: 01 October 2010

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Article

Osteoclast activation by receptor activator of NF-κB ligand enhances the mobilization of hematopoietic progenitor cells from the bone marrow in acute injury

Kyung-Ah Cho, Sun-Young Joo, Ho-Seong Han, Kyung-Ha Ryu, So-Youn Woo
Pages: 557-563
Published online on: 01 October 2010

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Article

Ursolic acid inhibits early lesions of diabetic nephropathy

Yi Zhou, Jian-Shuang Li, Xin Zhang, Ya-Jun Wu, Kun Huang, Ling Zheng
Pages: 565-570
Published online on: 01 October 2010

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Article Open Access

Role of cross-talk between the Smad2 and MAPK pathways in TGF-β1-induced collagen IV expression in mesangial cells

Weina Jiang, Yan Zhang, Huijuan Wu, Xin Zhang, Hualei Gan, Jianyong Sun, Qi Chen, Muyi Guo, Zhigang Zhang
Pages: 571-576
Published online on: 01 October 2010

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Article

Hypoxia and reoxygenation of primary human hepatocytes induce proteome changes of glucose metabolism, oxidative protection and peroxisomal function

Christoph W. Strey, Johannes Gestrich, Tobias Beckhaus, Rosa Maria Marquez-Pinilla, Elsie Oppermann, Christian Mönch, John D. Lambris, Michael Karas, Wolf O. Bechstein
Pages: 577-584
Published online on: 01 October 2010

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Article

Frequency and diversity of human immunodeficiency virus type 1 mutations associated with antiretroviral resistance among patients from Southern Brazil failing highly active antiretroviral therapy (HAART)

Flavia Figueiredo Saad, Helena Kaminami Morimoto, Susana Lilian Wiechmann, Ana Maria Bonametti, Luis Toshio Ueda, Tiemi Matsuo, Edna Maria Vissoci Reiche
Pages: 585-593
Published online on: 01 October 2010

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Article

Identification of CYP21A2 mutant alleles in Czech patients with 21-hydroxylase deficiency

Zuzana Vrzalová, Zuzana Hrubá, Eva St'ahlová Hrabincová, Slavka Pouchlá, Felix Votava, Stanislava Kolousková, Lenka Fajkusová
Pages: 595-603
Published online on: 01 October 2010

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Article Open Access

Connexin40 nonsense mutation in familial atrial fibrillation

Yi-Qing Yang, Xian-Ling Zhang, Xin-Hua Wang, Hong-Wei Tan, Hai-Feng Shi, Wei-Feng Jiang, Wei-Yi Fang, Xu Liu
Pages: 605-610
Published online on: 01 October 2010

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Article

Increased expression of the receptor for activation of NF-κB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes

Mamiko Hie, Ikuyo Tsukamoto
Pages: 611-618
Published online on: 01 October 2010

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Article

SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway Corrigendum in /10.3892/ijmm.2020.4803

Ping Chen, Liya Huang, Yongping Zhang, Minmin Qiao, Yaozong Yuan
Pages: 619-626
Published online on: 01 October 2010

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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