Open Access

Connexin40 nonsense mutation in familial atrial fibrillation

  • Authors:
    • Yi-Qing Yang
    • Xian-Ling Zhang
    • Xin-Hua Wang
    • Hong-Wei Tan
    • Hai-Feng Shi
    • Wei-Feng Jiang
    • Wei-Yi Fang
    • Xu Liu
  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/ijmm_00000505
  • Pages: 605-610
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Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with substantial morbidity and mortality. Genetic variants play important roles in the pathogenesis of AF. However, AF is a genetically heterogeneous disorder, and the genetic determinants in most patients with AF remain to be identified. In this study, the entire coding region of the connexin40 gene, encoding the cardiac gap junction membrane channel protein α5, was sequenced in 126 unrelated probands with familial AF. A novel heterozygous mutation, c.145C

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October 2010
Volume 26 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
APA
Yang, Y., Zhang, X., Wang, X., Tan, H., Shi, H., Jiang, W. ... Liu, X. (2010). Connexin40 nonsense mutation in familial atrial fibrillation . International Journal of Molecular Medicine, 26, 605-610. https://doi.org/10.3892/ijmm_00000505
MLA
Yang, Y., Zhang, X., Wang, X., Tan, H., Shi, H., Jiang, W., Fang, W., Liu, X."Connexin40 nonsense mutation in familial atrial fibrillation ". International Journal of Molecular Medicine 26.4 (2010): 605-610.
Chicago
Yang, Y., Zhang, X., Wang, X., Tan, H., Shi, H., Jiang, W., Fang, W., Liu, X."Connexin40 nonsense mutation in familial atrial fibrillation ". International Journal of Molecular Medicine 26, no. 4 (2010): 605-610. https://doi.org/10.3892/ijmm_00000505