Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice

  • Authors:
    • Pierre Watcho
    • Roman Stavniichuk
    • Pierre Tane
    • Hanna Shevalye
    • Yury Maksimchyk
    • Pal Pacher
    • Irina G. Obrosova
  • View Affiliations

  • Published online on: January 11, 2011     https://doi.org/10.3892/ijmm.2011.597
  • Pages:299-307
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Abstract

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy. C57Bl6/J mice with streptozotocin-induced diabetes of a 12-week duration, developed motor and sensory nerve conduction velocity deficits, thermal and mechanical hypoalgesia, tactile allodynia, and intra-epidermal nerve fiber loss. PMI-5011 (500 mg/kg/day for 7 weeks) alleviated diabetes-induced nerve conduction slowing, small sensory nerve fiber dysfunction, and increased intra-epidermal nerve fiber density. PMI-5011 blunted sciatic nerve and spinal cord 12/15-lipoxygenase activation and oxidative-nitrosative stress, without ameliorating hyperglycemia or reducing sciatic nerve sorbitol pathway intermediate accumulation. In conclusion, PMI-5011, a safe and non-toxic botanical extract, may find use in the treatment of diabetic peripheral neuropathy.

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March 2011
Volume 27 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2015 Impact Factor: 2.348
Ranked #22/123 Medicine Research and Experimental
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APA
Watcho, P., Stavniichuk, R., Tane, P., Shevalye, H., Maksimchyk, Y., Pacher, P., & Obrosova, I.G. (2011). Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice. International Journal of Molecular Medicine, 27, 299-307. https://doi.org/10.3892/ijmm.2011.597
MLA
Watcho, P., Stavniichuk, R., Tane, P., Shevalye, H., Maksimchyk, Y., Pacher, P., Obrosova, I. G."Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice". International Journal of Molecular Medicine 27.3 (2011): 299-307.
Chicago
Watcho, P., Stavniichuk, R., Tane, P., Shevalye, H., Maksimchyk, Y., Pacher, P., Obrosova, I. G."Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice". International Journal of Molecular Medicine 27, no. 3 (2011): 299-307. https://doi.org/10.3892/ijmm.2011.597