IL-17 expression is correlated with hepatitis B‑related liver diseases and fibrosis

  • Authors:
    • Liyun Wang
    • Shijun Chen
    • Keshu Xu
  • View Affiliations

  • Published online on: January 10, 2011     https://doi.org/10.3892/ijmm.2011.594
  • Pages: 385-392
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Abstract

IL-17-producing T cells (Th17) have been found to play important roles in several liver diseases, but few studies have evaluated the function of such cells in hepatitis B (HBV)‑related diseases, especially in hepatic fibrosis. In this study, we examined the expression of IL‑17 in patients with different chronic HBV-related diseases, and assessed the association between IL-17 expression and the degree of fibrosis. The method of immunohistochemistry was used to evaluate the localization of intrahepatic IL-17. We demonstrated significantly increased expression of IL‑17 in HBV-related chronic liver diseases, especially in liver fibrosis, and that the level of IL-17 is strongly correlated with the degree of fibrosis. Furthermore, we found that intrahepatic IL‑17 was mainly localized in the fibrosis region. Our data reveal important roles of IL-17 and IL-17-producing cells in the progression of HBV related chronic liver diseases, especially in the formation of liver fibrosis.

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March 2011
Volume 27 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Wang, L., Chen, S., & Xu, K. (2011). IL-17 expression is correlated with hepatitis B‑related liver diseases and fibrosis. International Journal of Molecular Medicine, 27, 385-392. https://doi.org/10.3892/ijmm.2011.594
MLA
Wang, L., Chen, S., Xu, K."IL-17 expression is correlated with hepatitis B‑related liver diseases and fibrosis". International Journal of Molecular Medicine 27.3 (2011): 385-392.
Chicago
Wang, L., Chen, S., Xu, K."IL-17 expression is correlated with hepatitis B‑related liver diseases and fibrosis". International Journal of Molecular Medicine 27, no. 3 (2011): 385-392. https://doi.org/10.3892/ijmm.2011.594