Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection

  • Authors:
    • Christoph W. Strey
    • Rosa Maria Marquez-Pinilla
    • Maciej M. Markiewski
    • Britta Siegmund
    • Elsie Oppermann
    • John D. Lambris
    • Wolf O. Bechstein
  • View Affiliations

  • Published online on: December 28, 2010     https://doi.org/10.3892/ijmm.2010.592
  • Pages: 447-454
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Identification of patients at risk of a complicated course after liver resection is crucial for adapting post-operative care. In the present study, we investigated the diagnostic value of the plasma levels of various cytokines obtained immediately after surgery. IL-6, IL-10, IL-8, monokine induced by interferon-γ (MIG), monocyte chemotactic protein-1 (MCP-1) and interferon-inducible protein-10 (IP-10) concentrations were measured in 26 patients after liver resection using a cytometric bead assay and were correlated with liver function, resectate weight, surgery duration, ischemia/reperfusion, hospitalization time and occurrence of complications. Patients with post-surgical complications showed distinctive patterns of IL-6 and IL-8 as early as minutes to hours after surgery. In addition, although pre-operative bilirubin in most patients remained within the normal range, a cut-off of 1 mg/dl separated the patients into groups with different profiles of IL-6, IL-8, and MCP-1 secretion and different likelihoods of experiencing post-operative complications (bilirubin levels ≥1.0 vs. <1.0 mg/dl; IL-6 (4 h): 701 vs. 265; IL-8 (6 h): 262 vs. 97 pg/ml; p<0.05 for both). Extended hospitalization, related to delayed recovery, was correlated with increased IL-8 and MCP-1 immediately after surgery. In conclusion, on the basis of these observations, we suggest that early measurement of post-operative levels of MCP-1, IL-6, and IL-8 can be used to identify individuals at risk of post-operative complications immediately after liver surgery.

Related Articles

Journal Cover

March 2011
Volume 27 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Strey, C.W., Marquez-Pinilla, R.M., Markiewski, M.M., Siegmund, B., Oppermann, E., Lambris, J.D., & Bechstein, W.O. (2011). Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection. International Journal of Molecular Medicine, 27, 447-454. https://doi.org/10.3892/ijmm.2010.592
MLA
Strey, C. W., Marquez-Pinilla, R. M., Markiewski, M. M., Siegmund, B., Oppermann, E., Lambris, J. D., Bechstein, W. O."Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection". International Journal of Molecular Medicine 27.3 (2011): 447-454.
Chicago
Strey, C. W., Marquez-Pinilla, R. M., Markiewski, M. M., Siegmund, B., Oppermann, E., Lambris, J. D., Bechstein, W. O."Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection". International Journal of Molecular Medicine 27, no. 3 (2011): 447-454. https://doi.org/10.3892/ijmm.2010.592