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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2011 Volume 28 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 28 Issue 6

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Article

Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line

  • Authors:
    • Weiwei Chen
    • Feng Wei
    • Jing Xu
    • Yucai Wang
    • Longbang Chen
    • Jinghua Wang
    • Xiaoxiang Guan

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China, Department of Medical Oncology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, P.R. China
  • Pages: 985-991
    |
    Published online on: September 1, 2011
       https://doi.org/10.3892/ijmm.2011.790
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Abstract

Trastuzumab has efficacy to improve the effect of cytotoxic drugs, such as paclitaxel and anthracyclin, against HER2-overexpressing breast cancer cells. Sodium butyrate (NaB), a histone deacetylase inhibitor, is known to have antitumoral properties. However, whether and how trastuzumab possesses the potential to synergize the anti-tumor effect of NaB on breast cancer cells is still equivocal. To elucidate whether combined treatment with NaB and trastuzumab exerts anti-tumor effects on a HER2-overexpressing breast cancer cell line, SKBR3 cells were treated with NaB alone or in combination with trastuzumab, and the effects on proliferation and cell cycle progression were analyzed. Combinatory treatment with NaB (4 mmol/l) and trastuzumab (20 µg/ml) significantly increased the growth-inhibitory effect on SKBR3 breast cancer cells, in comparison to NaB or trastuzumab treatment alone. The growth-inhibitory effect of the combination of NaB and trastuzumab was accompanied by elevated mRNA and protein levels of the cyclin-dependent kinase inhibitor p27Kip1. In contrast, this effect was absent in HER2-negative HCC1937 cells. In conclusion, trastuzumab significantly improved the antitumor effect of NaB on HER2-overexpressing breast cancer cell line in vitro.

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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Wei F, Xu J, Wang Y, Chen L, Wang J and Guan X: Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line. Int J Mol Med 28: 985-991, 2011.
APA
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., & Guan, X. (2011). Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line. International Journal of Molecular Medicine, 28, 985-991. https://doi.org/10.3892/ijmm.2011.790
MLA
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., Guan, X."Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line". International Journal of Molecular Medicine 28.6 (2011): 985-991.
Chicago
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., Guan, X."Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line". International Journal of Molecular Medicine 28, no. 6 (2011): 985-991. https://doi.org/10.3892/ijmm.2011.790
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Wei F, Xu J, Wang Y, Chen L, Wang J and Guan X: Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line. Int J Mol Med 28: 985-991, 2011.
APA
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., & Guan, X. (2011). Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line. International Journal of Molecular Medicine, 28, 985-991. https://doi.org/10.3892/ijmm.2011.790
MLA
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., Guan, X."Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line". International Journal of Molecular Medicine 28.6 (2011): 985-991.
Chicago
Chen, W., Wei, F., Xu, J., Wang, Y., Chen, L., Wang, J., Guan, X."Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line". International Journal of Molecular Medicine 28, no. 6 (2011): 985-991. https://doi.org/10.3892/ijmm.2011.790
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