Insulin-like growth factor-1 protects against prion peptide-induced cell death in neuronal cells via inhibition of Bax translocation

Park,Yang-Gyu; Jeong,Jae-Kyo; Moon,Myung-Hee; Lee,Ju-Hee; Lee,You-Jin; Seol,Jae-Won; Kim,Shang-Jin; Kang,Seog-Jin; Park,Sang-Youel

doi:10.3892/ijmm.2012.1087

Insulin-like growth factor-1 protects against prion peptide-induced cell death in neuronal cells via inhibition of Bax translocation

Authors:
- Yang-Gyu Park
- Jae-Kyo Jeong
- Myung-Hee Moon
- Ju-Hee Lee
- You-Jin Lee
- Jae-Won Seol
- Shang-Jin Kim
- Seog-Jin Kang
- Sang-Youel Park
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Affiliations: Korea Zoonoses Research Institute, Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea, Technology Service Division, National Institute of Animal Science, Rural Development Administration, Suwon, Gyeonggi-do 441-706, Republic of Korea
Published online on: August 8, 2012 https://doi.org/10.3892/ijmm.2012.1087
Pages: 1069-1074

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Abstract

Insulin-like growth factor-1 (IGF-1) is one of the most important components of bovine colostrum. It exhibits antiapoptotic and antioxidative activities. Prion diseases are neurodegenerative disorders caused by cell death through mitochondrial dysfunction and increasing generation of reactive oxygen species (ROS). This study examined the protective effect of IGF-1 on residues 106-126 of the cellular prion protein [PrP (106-126)]-mediated mitochondrial neurotoxicity and oxidative stress. In SH-SY5Y human neuronal cells, treatment with PrP (106-126) decreased the cell viability and IGF-1 pretreatment markedly blocked the PrP (106-126)-induced neuronal cell death. IGF-1 inhibited PrP (106-126)-induced intracellular ROS generation and mitochondrial oxidative stress. In addition, IGF-1 blocked the translocation of the Bax protein to the mitochondria induced by PrP (106-126). These results demonstrate that IGF-1 protects neuronal cells against PrP (106-126)-mediated neurotoxicity through an antioxidative effect and blockage of mitochondrial Bax translocation. The results also suggest that regulation of IGF-1 secretion may have a therapeutic potential in the management of mitochondrial dysfunction and oxidative stress-induced neurodegeneration.

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