Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer

  • Authors:
    • Se-Lim Kim
    • Soo-Teik Lee
    • Kieu Thi Thu Trang
    • Seong Hun Kim
    • In Hee Kim
    • Seung Ok Lee
    • Dae Ghon Kim
    • Sang-Wook Kim
  • View Affiliations

  • Published online on: February 25, 2014     https://doi.org/10.3892/ijmm.2014.1669
  • Pages: 1261-1267
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Abstract

Parthenolide (PT) is responsible for the bioactivities of feverfew (Tanacetum parthenium). Apart from its potent anti-inflammatory effects, this compound has been reported to induce apoptosis in various cancer cells. However, little is known about its role in the process of tumor angiogenesis. In the present study, we investigated the effects and potential mechanisms of action of PT on angiogenesis in human colorectal cancer (CRC). The anti-angiogenic effects of PT were evaluated in cultured human umbilical vein endothelial cells (HUVECs) and in the human CRC cell lines, HT-29, SW620 and HCT116. PT markedly inhibited vascular cell migration and capillary-like structure formation even at a dose which had not effects on cell viability. PT also suppressed the expression of angiogenic biomarker proteins [vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and VEGFR2] in both the HUVECs and CRC cells. Additionally, PT effectively inhibited tumor neovascularization in a HT-29 xenograft model. These results indicate that PT suppresses angiogenesis by reducing the expression of VEGF and its receptors and may be a viable drug candidate in anti-angiogenesis therapies for human CRC.

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May-2014
Volume 33 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kim S, Lee S, Trang KT, Kim SH, Kim IH, Lee SO, Kim DG and Kim S: Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. Int J Mol Med 33: 1261-1267, 2014
APA
Kim, S., Lee, S., Trang, K.T., Kim, S.H., Kim, I.H., Lee, S.O. ... Kim, S. (2014). Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. International Journal of Molecular Medicine, 33, 1261-1267. https://doi.org/10.3892/ijmm.2014.1669
MLA
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33.5 (2014): 1261-1267.
Chicago
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33, no. 5 (2014): 1261-1267. https://doi.org/10.3892/ijmm.2014.1669