|
1
|
Donnan GA, Fisher M, Macleod M and Davis
SM: Stroke. Lancet. 371:1612–1623. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Nour M, Scalzo F and Liebeskind DS:
Ischemia-reperfusion injury in stroke. Interv Neurol. 1:185–199.
2013. View Article : Google Scholar
|
|
3
|
Zhao H, Sapolsky RM and Steinberg GK:
Interrupting reperfusion as a stroke therapy: ischemic
postconditioning reduces infarct size after focal ischemia in rats.
J Cereb Blood Flow Metab. 26:1114–1121. 2006.PubMed/NCBI
|
|
4
|
Eltzschig HK and Eckle T: Ischemia and
reperfusion - from mechanism to translation. Nat Med. 17:1391–1401.
2011. View
Article : Google Scholar : PubMed/NCBI
|
|
5
|
Glick D, Barth S and Macleod KF:
Autophagy: cellular and molecular mechanisms. J Pathol. 221:3–12.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hotchkiss RS, Strasser A, McDunn JE and
Swanson PE: Cell death. N Engl J Med. 361:1570–1583. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Martínez-Borra J and López-Larrea C:
Autophagy and self-defense. Adv Exp Med Biol. 738:169–184. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tan CC, Yu JT, Tan MS, Jiang T, Zhu XC and
Tan L: Autophagy in aging and neurodegenerative diseases:
implications for pathogenesis and therapy. Neurobiol Aging.
35:941–957. 2014. View Article : Google Scholar
|
|
9
|
Wen YD, Sheng R, Zhang LS, Han R, Zhang X,
Zhang XD, Han F, Fukunaga K and Qin ZH: Neuronal injury in rat
model of permanent focal cerebral ischemia is associated with
activation of autophagic and lysosomal pathways. Autophagy.
4:762–769. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Shi R, Weng J, Zhao L, Li XM, Gao TM and
Kong J: Excessive autophagy contributes to neuron death in cerebral
ischemia. CNS Neurosci Ther. 18:250–260. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang JY, Xia Q, Chu KT, Pan J, Sun LN,
Zeng B, Zhu YJ, Wang Q, Wang K and Luo BY: Severe global cerebral
ischemia-induced programmed necrosis of hippocampal CA1 neurons in
rat is prevented by 3-methyladenine: a widely used inhibitor of
autophagy. J Neuropathol Exp Neurol. 70:314–322. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Nah J, Yuan J and Jung YK: Autophagy in
neurodegenerative diseases: from mechanism to therapeutic approach.
Mol Cells. 38:381–389. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mochida K, Oikawa Y, Kimura Y, Kirisako H,
Hirano H, Ohsumi Y and Nakatogawa H: Receptor-mediated selective
autophagy degrades the endoplasmic reticulum and the nucleus.
Nature. 522:359–362. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Tanida I: Autophagosome formation and
molecular mechanism of autophagy. Antioxid Redox Signal.
14:2201–2214. 2011. View Article : Google Scholar
|
|
15
|
Tanida I, Ueno T and Kominami E: LC3 and
Autophagy. Methods Mol Biol. 445:77–88. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Mizushima N, Yoshimori T and Ohsumi Y: The
role of Atg proteins in autophagosome formation. Annu Rev Cell Dev
Biol. 27:107–132. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Dooley HC, Razi M, Polson HE, Girardin SE,
Wilson MI and Tooze SA: WIPI2 links LC3 conjugation with PI3P,
autophagosome formation, and pathogen clearance by recruiting
Atg12-5-16L1. Mol Cell. 55:238–252. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kim YM, Jung CH, Seo M, Kim EK, Park JM,
Bae SS and Kim DH: mTORC1 phosphorylates UVRAG to negatively
regulate autophagosome and endosome maturation. Mol Cell.
57:207–218. 2015. View Article : Google Scholar
|
|
19
|
Hosokawa N, Hara T, Kaizuka T, Kishi C,
Takamura A, Miura Y, Iemura S, Natsume T, Takehana K and Yamada N:
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200
complex required for autophagy. Mol Biol Cell. 20:1981–1991. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Szymańska P, Martin KR, MacKeigan JP,
Hlavacek WS and Lipniacki T: Computational analysis of an
autophagy/translation switch based on mutual inhibition of MTORC1
and ULK1. PLoS One. 10:e01165502015. View Article : Google Scholar
|
|
21
|
Denton D, Nicolson S and Kumar S: Cell
death by autophagy: facts and apparent artefacts. Cell Death
Differ. 19:87–95. 2012. View Article : Google Scholar :
|
|
22
|
Puyal J, Vaslin A, Mottier V and Clarke
PG: Postischemic treatment of neonatal cerebral ischemia should
target autophagy. Ann Neurol. 66:378–389. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wei K, Wang P and Miao CY: A double-edged
sword with therapeutic potential: an updated role of autophagy in
ischemic cerebral injury. CNS Neurosci Ther. 18:879–886. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Rami A and Kögel D: Apoptosis meets
autophagy-like cell death in the ischemic penumbra: two sides of
the same coin? Autophagy. 4:422–426. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Tanida I: Autophagy basics. Microbiol
Immunol. 55:1–11. 2011. View Article : Google Scholar
|
|
26
|
Russell RC, Tian Y, Yuan H, Park HW, Chang
YY, Kim J, Kim H, Neufeld TP, Dillin A and Guan KL: ULK1 induces
autophagy by phosphorylating Beclin-1 and activating VPS34 lipid
kinase. Nat Cell Biol. 15:741–750. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Nazarko VY and Zhong Q: ULK1 targets
Beclin-1 in autophagy. Nat Cell Biol. 15:727–728. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Chen A, Lin Z, Lan L, Xie G, Huang J, Lin
J, Peng J, Tao J and Chen L: Electroacupuncture at the Quchi and
Zusanli acupoints exerts neuroprotective role in cerebral
ischemia-reperfusion injured rats via activation of the PI3K/Akt
pathway. Int J Mol Med. 30:791–796. 2012.PubMed/NCBI
|
|
29
|
Xue X, You Y, Tao J, Ye X, Huang J, Yang
S, Lin Z, Hong Z, Peng J and Chen L: Electro-acupuncture at points
of Zusanli and Quchi exerts anti-apoptotic effect through the
modulation of PI3K/Akt signaling pathway. Neurosci Lett. 558:14–19.
2014. View Article : Google Scholar
|
|
30
|
Du F and Liu S: Electroacupuncture with
high frequency at acupoint ST-36 induces regeneration of lost
enteric neurons in diabetic rats via GDNF and PI3k/Akt signal
pathway. Am J Physiol Regul Integr Comp Physiol. 309:R109–R118.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wu YT, Tan HL, Huang Q, Ong CN and Shen
HM: Activation of the PI3K-Akt-mTOR signaling pathway promotes
necrotic cell death via suppression of autophagy. Autophagy.
5:824–834. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Heras-Sandoval D, Pérez-Rojas JM,
Hernández-Damián J and Pedraza-Chaverri J: The role of
PI3K/AKT/mTOR pathway in the modulation of autophagy and the
clearance of protein aggregates in neurodegeneration. Cell Signal.
26:2694–2701. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Longa EZ, Weinstein PR, Carlson S and
Cummins R: Reversible middle cerebral artery occlusion without
craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Huang J, Ye X, You Y, Liu W, Gao Y, Yang
S, Peng J, Hong Z, Tao J and Chen L: Electroacupuncture promotes
neural cell proliferation in vivo through activation of the ERK1/2
signaling pathway. Int J Mol Med. 33:1547–1553. 2014.PubMed/NCBI
|
|
35
|
Neumann M, Wang Y, Kim S, Hong SM, Jeng L,
Bilgen M and Liu J: Assessing gait impairment following
experimental traumatic brain injury in mice. J Neurosci Methods.
176:34–44. 2009. View Article : Google Scholar :
|
|
36
|
Encarnacion A, Horie N, Keren-Gill H,
Bliss TM, Steinberg GK and Shamloo M: Long-term behavioral
assessment of function in an experimental model for ischemic
stroke. J Neurosci Methods. 196:247–257. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Wang Y, Yoshimura R, Manabe H, Schretter
C, Clarke R, Cai Y, Fitzgerald M and Lee KS: Trans-sodium
crocetinate improves outcomes in rodent models of occlusive and
hemorrhagic stroke. Brain Res. 1583:245–254. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu Y, Ao LJ, Lu G, Leong E, Liu Q, Wang
XH, Zhu XL, Sun TF, Fei Z, Jiu T, et al: Quantitative gait analysis
of long-term locomotion deficits in classical unilateral striatal
intracerebral hemorrhage rat model. Behav Brain Res. 257:166–177.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Koopmans GC, Deumens R, Honig WM, Hamers
FP, Steinbusch HW and Joosten EA: The assessment of locomotor
function in spinal cord injured rats: the importance of objective
analysis of coordination. J Neurotrauma. 22:214–225. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Dupont N, Orhon I, Bauvy C and Codogno P:
Autophagy and autophagic flux in tumor cells. Methods Enzymol.
543:73–88. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Mauvezin C, Ayala C, Braden CR, Kim J and
Neufeld TP: Assays to monitor autophagy in Drosophila. Methods.
68:134–139. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kabeya Y, Mizushima N, Ueno T, Yamamoto A,
Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a
mammalian homologue of yeast Apg8p, is localized in autophagosome
membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Li YC, He SM, He ZX, Li M, Yang Y, Pang
JX, Zhang X, Chow K, Zhou Q and Duan W: Plumbagin induces apoptotic
and autophagic cell death through inhibition of the PI3K/Akt/mTOR
pathway in human non-small cell lung cancer cells. Cancer Lett.
344:239–259. 2014. View Article : Google Scholar
|
|
44
|
Li X, Luo P, Wang Q and Xiong L:
Electroacupuncture pretreatment as a novel avenue to protect brain
against ischemia and reperfusion injury. Evid Based Complement
Alternat Med. 2012:1953972012. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Liu SY, Hsieh CL, Wei TS, Liu PT, Chang YJ
and Li TC: Acupuncture stimulation improves balance function in
stroke patients: a single-blinded controlled, randomized study. Am
J Chin Med. 37:483–494. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Wayne PM, Krebs DE, Macklin EA, Schnyer R,
Kaptchuk TJ, Parker SW, Scarborough DM, McGibbon CA, Schaechter JD,
Stein J and Stason WB: Acupuncture for upper-extremity
rehabilitation in chronic stroke: a randomized sham-controlled
study. Arch Phys Med Rehabil. 86:2248–2255. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Zhang GC, Fu WB, Xu NG, Liu JH, Zhu XP,
Liang ZH, Huang YF and Chen YF: Meta analysis of the curative
effect of acupuncture on post-stroke depression. J Tradit Chin Med.
32:6–11. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Lim SM, Yoo J, Lee E, Kim HJ, Shin S, Han
G and Ahn HS: Acupuncture for spasticity after stroke: a systematic
review and meta-analysis of randomized controlled trials. Evid
Based Complement Alternat Med. 2015:8703982015. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Yang HY, Liu TY, Wang YH, Ying SG, Zheng
CY, Kuai L and Gao M: Acupoint electrogymnastics therapy for
treatment of apoplectic hemiplegia: a multicenter randomized
control study. Zhongguo Zhen Jiu. 28:635–638. 2008.In Chinese.
PubMed/NCBI
|
|
50
|
Feng X, Yang S, Liu J, Huang J, Peng J,
Lin J, Tao J and Chen L: Electroacupuncture ameliorates cognitive
impairment through inhibition of NF-κB-mediated neuronal cell
apoptosis in cerebral ischemia-reperfusion injured rats. Mol Med
Rep. 7:1516–1522. 2013.PubMed/NCBI
|
|
51
|
Zhang TS, Yang L, Hu R, Qiao XL, Yang X
and Liu XG: Effect of electroacupuncture on the contents of
excitatory amino acids in cerebral tissue at different time courses
in rats with cerebral ischemia and reperfusion injury. Zhen Ci Yan
Jiu. 32:234–236. 2007.In Chinese. PubMed/NCBI
|
|
52
|
Vandeputte C, Taymans JM, Casteels C, Coun
F, Ni Y, Van Laere K and Baekelandt V: Automated quantitative gait
analysis in animal models of movement disorders. BMC Neurosci.
11:922010. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Lubjuhn J, Gastens A, von Wilpert G,
Bargiotas P, Herrmann O, Murikinati S, Rabie T, Marti HH, Amende I,
Hampton TG and Schwaninger M: Functional testing in a mouse stroke
model induced by occlusion of the distal middle cerebral artery. J
Neurosci Methods. 184:95–103. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wang Y, Bontempi B, Hong SM, Mehta K,
Weinstein PR, Abrams GM and Liu J: A comprehensive analysis of gait
impairment after experimental stroke and the therapeutic effect of
environmental enrichment in rats. J Cereb Blood Flow Metab.
28:1936–1950. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Xu M and Zhang HL: Death and survival of
neuronal and astrocytic cells in ischemic brain injury: a role of
autophagy. Acta Pharmacol Sin. 32:1089–1099. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Xu F, Gu JH and Qin ZH: Neuronal autophagy
in cerebral ischemia. Neurosci Bull. 28:658–666. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Xing S, Zhang Y, Li J, Zhang J, Li Y, Dang
C, Li C, Fan Y, Yu J, Pei Z and Zeng J: Beclin 1 knockdown inhibits
autophagic activation and prevents the secondary neurodegenerative
damage in the ipsilateral thalamus following focal cerebral
infarction. Autophagy. 8:63–76. 2012. View Article : Google Scholar
|
|
58
|
Rami A, Langhagen A and Steiger S: Focal
cerebral ischemia induces upregulation of Beclin 1 and
autophagy-like cell death. Neurobiol Dis. 29:132–141. 2008.
View Article : Google Scholar
|
|
59
|
Levine B, Packer M and Codogno P:
Development of autophagy inducers in clinical medicine. J Clin
Invest. 125:14–24. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Wu Z, Zou Z, Zou R, Zhou X and Cui S:
Electroacupuncture pretreatment induces tolerance against cerebral
ischemia/reperfusion injury through inhibition of the autophagy
pathway. Mol Med Rep. 11:4438–4446. 2015.PubMed/NCBI
|
|
61
|
Inoki K, Kim J and Guan KL: AMPK and mTOR
in cellular energy homeostasis and drug targets. Annu Rev Pharmacol
Toxicol. 52:381–400. 2012. View Article : Google Scholar
|
|
62
|
Leung EY, Askarian-Amiri M, Finlay GJ,
Rewcastle GW and Baguley BC: Potentiation of growth inhibitory
responses of the mTOR inhibitor everolimus by dual mTORC1/2
inhibitors in cultured breast cancer cell lines. PLoS One.
10:e01314002015. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Zha QB, Zhang XY, Lin QR, Xu LH, Zhao GX,
Pan H, Zhou D, Ouyang DY, Liu ZH and He XH: Cucurbitacin E induces
autophagy via downregulating mTORC1 signaling and upregulating AMPK
activity. PLoS One. 10:e01243552015. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wirth M, Joachim J and Tooze SA:
Autophagosome formation - the role of ULK1 and Beclin1-PI3KC3
complexes in setting the stage. Semin Cancer Biol. 23:301–309.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Rami A: Upregulation of Beclin 1 in the
ischemic penumbra. Autophagy. 4:227–229. 2008. View Article : Google Scholar
|
|
66
|
Zheng YQ, Liu JX, Li XZ, Xu L and Xu YG:
RNA interference-mediated downregulation of Beclin1 attenuates
cerebral ischemic injury in rats. Acta Pharmacol Sin. 30:919–927.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Klionsky DJ, Abdalla FC, Abeliovich H,
Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M,
Agostinis P, Aguirre-Ghiso JA, et al: Guidelines for the use and
interpretation of assays for monitoring autophagy. Autophagy.
8:445–544. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Gao L, Jiang T, Guo J, Liu Y, Cui G, Gu L,
Su L and Zhang Y: Inhibition of autophagy contributes to ischemic
postconditioning-induced neuroprotection against focal cerebral
ischemia in rats. PLoS One. 7:e460922012. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Buckley KM, Hess DL, Sazonova IY,
Periyasamy-Thandavan S, Barrett JR, Kirks R, Grace H, Kondrikova G,
Johnson MH, Hess DC, et al: Rapamycin up-regulation of autophagy
reduces infarct size and improves outcomes in both permanent MCAL,
and embolic MCAO, murine models of stroke. Exp Transl Stroke Med.
6:82014. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Zheng Y, Hou J, Liu J, Yao M, Li L, Zhang
B, Zhu H and Wang Z: Inhibition of autophagy contributes to
melatonin-mediated neuroprotection against transient focal cerebral
ischemia in rats. J Pharmacol Sci. 124:354–364. 2014. View Article : Google Scholar : PubMed/NCBI
|
