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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2016 Volume 37 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Experimental models of Alzheimer's disease for deciphering the pathogenesis and therapeutic screening (Review)

Xueyuan Li, Xinjie Bao, Renzhi Wang
Pages: 271-283
Published online on: 10 December 2015

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Article Open Access

Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R

Shuangxin Liu, Weiping Zhu, Sijia Li, Jianchao Ma, Huitao Zhang, Zhonghe Li, Li Zhang, Bin Zhang, Zhuo Li, Xinling Liang, Wei Shi
Pages: 284-292
Published online on: 07 December 2015

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Article Open Access

Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes

Sheila C. Wang, Lin Ye, Andrew J. Sanders, Fiona Ruge, Keith G. Harding, Wen G. Jiang
Pages: 293-298
Published online on: 11 December 2015

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Article Open Access

In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury

Caterina Constantinou, Yiorgos Apidianakis, Nikolaos Psychogios, Valeria Righi, Michael N. Mindrinos, Nadeem Khan, Harold M. Swartz, Hazel H. Szeto, Ronald G. Tompkins, Laurence G. Rahme, A. Aria Tzika
Pages: 299-308
Published online on: 08 December 2015

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Article Open Access

Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway

Weilin Liu, Guanhao Shang, Shanli Yang, Jia Huang, Xiehua Xue, Yunjiao Lin, Yi Zheng, Xian Wang, Lulu Wang, Ruhui Lin, Jing Tao, Lidian Chen
Pages: 309-318
Published online on: 07 December 2015

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Article Open Access

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis

Yuji Shimamoto, Mamoru Nukatsuka, Teiji Takechi, Masakazu Fukushima
Pages: 319-328
Published online on: 10 December 2015

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Article Open Access

Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway

Zhiguang Chen, Jinqi Xue, Tao Shen, Shuai Mu, Qin Fu
Pages: 329-338
Published online on: 11 December 2015

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Article Open Access

Inhibitory effects of amines from Citrus reticulata on bleomycin-induced pulmonary fibrosis in rats

Xian-Mei Zhou, Zhen-Dong Cao, Na Xiao, Qi Shen, Jian-Xin Li
Pages: 339-346
Published online on: 15 December 2015

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Article Open Access

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB

Qiyue Gao, Yang Liu, Yan Wu, Qiang Zhao, Lijun Wang, Shanshan Gao, Wen Wen, Weiping Zhang, Ning Guo, Juan Zhou, Zuyi Yuan
Pages: 347-358
Published online on: 11 December 2015

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Article Open Access

Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions

Hai-Yan Jia, Ying Shi, Long-Fei Luo, Guan Jiang, Qiong Zhou, Shi-Zheng Xu, Tie-Chi Lei
Pages: 359-368
Published online on: 23 December 2015

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Article Open Access

Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt

Yuanhui Lai, Xinpei Yu, Xiaohong Lin, Shanyang He
Pages: 369-377
Published online on: 21 December 2015

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Article Open Access

Neuroprotective effects of 20(S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells

Dong-Ho Bak, Hyung Don Kim, Young Ock Kim, Chun Geun Park, Seung-Yun Han, Jwa-Jin Kim
Pages: 378-386
Published online on: 21 December 2015

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Article Open Access

Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein

Sin-Hye Park, Min Jae Shin, Dae Won Kim, Jinseu Park, Soo Young Choi, Young-Hee Kang
Pages: 387-397
Published online on: 23 December 2015

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Article

EGCG attenuates atherosclerosis through the Jagged-1/Notch pathway

Jianguo Yin, Fang Huang, Yuhong Yi, Liang Yin, Daoquan Peng
Pages: 398-406
Published online on: 01 December 2015

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Article

High-content screening identifies inhibitors of the nuclear translocation of ATF6

Chun-Lei Liu, Xin Li, Lu Gan, Yun-Yun He, Li-Li Wang, Kun-Lun He
Pages: 407-414
Published online on: 23 December 2015

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Article

The downregulation of SnoN expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-β1 signaling

Xiuji Li, Zongli Diao, Jiaxiang Ding, Ruixia Liu, Liyan Wang, Wen Huang, Wenhu Liu
Pages: 415-422
Published online on: 31 December 2015

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Article

A deficiency in cold-inducible RNA-binding protein accelerates the inflammation phase and improves wound healing

Juan Pablo Idrovo, Asha Jacob, Weng Lang Yang, Zhimin Wang, Hao Ting Yen, Jeffrey Nicastro, Gene F. Coppa, Ping Wang
Pages: 423-428
Published online on: 07 January 2016

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Article

Damage to dopaminergic neurons is mediated by proliferating cell nuclear antigen through the p53 pathway under conditions of oxidative stress in a cell model of Parkinson's disease

Da-Wei Li, Guang-Ren Li, Bei-Lin Zhang, Jing-Jing Feng, Hua Zhao
Pages: 429-435
Published online on: 10 December 2015

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Article

Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling

Xiaolin Wu, Wenwei Liu, Hong Jiang, Jing Chen, Jichun Wang, Rui Zhu, Bin Li
Pages: 436-444
Published online on: 10 December 2015

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Article

A novel HAND2 loss-of-function mutation responsible for tetralogy of Fallot

Cai-Xia Lu, Hai-Rong Gong, Xing-Yuan Liu, Juan Wang, Cui-Mei Zhao, Ri-Tai Huang, Song Xue, Yi-Qing Yang
Pages: 445-451
Published online on: 15 December 2015

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Article

Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes

Jin-Woo Jeong, Hye Hyeon Lee, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Gi-Young Kim, Cheol Park, Ho Kyoung Kim, Young Whan Choi, Yung Hyun Choi
Pages: 452-460
Published online on: 23 December 2015

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Article

Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome

Atsushi Watanabe, Kazumi Satoh, Tomoko Maniwa, Ken-Ichi Matsumoto
Pages: 461-467
Published online on: 18 December 2015

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Article

Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through the GPCR/PKC and PKA pathways

Zi-Li Yu, Dian-Qi Li, Xiang-Yu Huang, Xin Xing, Ru-Qing Yu, Zhi Li, Zu-Bing Li
Pages: 468-474
Published online on: 07 January 2016

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Article

A fraction from Dojuksan 30% ethanol extract exerts its anti-inflammatory effects through Nrf2-dependent heme oxygenase-1 expression

Dong-Sung Lee, Kyoung-Su Kim, Wonmin Ko, Gi-Sang Bae, Sung-Joo Park, Jun-Hyeog Jang, Hyuncheol Oh, Youn-Chul Kim
Pages: 475-484
Published online on: 07 December 2015

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Article

miR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein

Jiantao Sun, Zhiqiang Fan, Shuaiqi Lu, Jinhui Yang, Tongtong Hao, Qingxiang Huo
Pages: 485-492
Published online on: 05 January 2016

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Article

Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo

Jie Qin, Lin Wang, Yue Sun, Xiaolin Sun, Chaoju Wen, Mahdi Shahmoradi, Yanmin Zhou
Pages: 493-500
Published online on: 18 December 2015

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Article

Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated allergic response in RBL‑2H3 cells

Jae-Myung Yoo, Ju Hye Yang, Hye Jin Yang, Won-Kyung Cho, Jin Yeul Ma
Pages: 501-508
Published online on: 28 December 2015

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Article

hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes

Xin Lu, Jin Lin, Jin Jin, Wenwei Qian, Xisheng Weng
Pages: 509-516
Published online on: 23 December 2015

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Article

Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-κB in vitro but have a low impact on hepatocellular cells

B. Relja, N. Omid, N. Wagner, K. Mörs, I. Werner, E. Juengel, M. Perl, I. Marzi
Pages: 517-525
Published online on: 11 December 2015

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Article

Amygdalin inhibits the growth of renal cell carcinoma cells in vitro

Eva Juengel, Anita Thomas, Jochen Rutz, Jasmina Makarevic, Igor Tsaur, Karen Nelson, Axel Haferkamp, Roman A. Blaheta
Pages: 526-532
Published online on: 21 December 2015

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Article

Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts

Gen Kuroyanagi, Takanobu Otsuka, Naohiro Yamamoto, Shingo Kainuma, Reou Ohguchi, Kazuhiko Fujita, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 533-541
Published online on: 07 January 2016

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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