Open Access

Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity

  • Authors:
    • Xiao-Hui Li
    • Yuan-Yuan Deng
    • Fei Li
    • Jing-Shan Shi
    • Qi-Hai Gong
  • View Affiliations

  • Published online on: August 9, 2016     https://doi.org/10.3892/ijmm.2016.2701
  • Pages: 1152-1160
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alzheimer's disease (AD) is known to be caused by the accumulation of amyloid-β peptide (Aβ). The accumulation of Aβ has been shown to cause learning and memory impairment in rats, and it has been shown that hydrogen sulfide donors, such as sodium hydrosulfide (NaHS) can attenuate these effects. However, the underlying mechanisms have not yet been fully eludicated. This study was designed to investigate whether NaHS attenuates the inflammation and apoptosis induced by Aβ. We demonstrated that NaHS attenuated Aβ25‑35-induced neuronal reduction and apoptosis, and inhibited the activation of pro-caspase-3. It also decreased the protein expresion of phosphodiesterase 5 (PDE5) in the hippocampus of the rats. In addition, NaHS upregulated the expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ, but it did not affect the expression of PPAR-β. Moreover, the Aβ25‑35‑exposed rats exhibited a decrease in IκB-α degradation and an increase in nuclear factor-κB (NF-κB) p65 phosphorylation levels, whereas these effects were attenuated by NaHS. Our data suggest that NaHS prevents Aβ-induced neurotoxicity via the upregulation of PPAR-α and PPAR-γ and the inhibition of PDE5. Hence NaHS may prove to be beneficial in the treatment of AD.
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October-2016
Volume 38 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Li X, Deng Y, Li F, Shi J and Gong Q: Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity. Int J Mol Med 38: 1152-1160, 2016
APA
Li, X., Deng, Y., Li, F., Shi, J., & Gong, Q. (2016). Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity. International Journal of Molecular Medicine, 38, 1152-1160. https://doi.org/10.3892/ijmm.2016.2701
MLA
Li, X., Deng, Y., Li, F., Shi, J., Gong, Q."Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity". International Journal of Molecular Medicine 38.4 (2016): 1152-1160.
Chicago
Li, X., Deng, Y., Li, F., Shi, J., Gong, Q."Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity". International Journal of Molecular Medicine 38, no. 4 (2016): 1152-1160. https://doi.org/10.3892/ijmm.2016.2701