Oxidative stress in the trabecular meshwork (Review)

  • Authors:
    • Jing Zhao
    • Shuang Wang
    • Wei Zhong
    • Ben Yang
    • Lixia Sun
    • Yajuan Zheng
  • View Affiliations

  • Published online on: August 24, 2016     https://doi.org/10.3892/ijmm.2016.2714
  • Pages: 995-1002
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Abstract

Glaucoma is the second leading cause of blindness worldwide and elevated intraocular pressure (IOP) is the most important risk factor. High IOP usually occurs as a result of an increase in aqueous humor outflow resistance at the trabecular meshwork (TM). An abnormal TM contributes to the development of glaucoma. Oxidative stress and vascular damage are considered two major cellular factors that lead to alterations in the TM. In this review, we discuss the findings related to oxidative damage to the TM, including the sources of oxidative stress in the TM such as the mitochondria, peroxisomes, endoplasmic reticulum, membrane, cytosol and exogenous factors. We also discuss antioxidants and clinical studies related to protection against oxidative stress in the TM. Although many questions remain unanswered, it is becoming increasingly clear that oxidative stress-induced damage to the TM is related to glaucoma. This may inspire new studies to find better and more stable antioxidants, and better models with which to elucidate the mechanisms involved, and to determine whether in vitro findings translate into in vivo observations. The regulation of the oxidative/redox balance may be the ultimate target for protecting the TM from oxidative stress and preventing glaucoma.
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October-2016
Volume 38 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao J, Wang S, Zhong W, Yang B, Sun L and Zheng Y: Oxidative stress in the trabecular meshwork (Review). Int J Mol Med 38: 995-1002, 2016.
APA
Zhao, J., Wang, S., Zhong, W., Yang, B., Sun, L., & Zheng, Y. (2016). Oxidative stress in the trabecular meshwork (Review). International Journal of Molecular Medicine, 38, 995-1002. https://doi.org/10.3892/ijmm.2016.2714
MLA
Zhao, J., Wang, S., Zhong, W., Yang, B., Sun, L., Zheng, Y."Oxidative stress in the trabecular meshwork (Review)". International Journal of Molecular Medicine 38.4 (2016): 995-1002.
Chicago
Zhao, J., Wang, S., Zhong, W., Yang, B., Sun, L., Zheng, Y."Oxidative stress in the trabecular meshwork (Review)". International Journal of Molecular Medicine 38, no. 4 (2016): 995-1002. https://doi.org/10.3892/ijmm.2016.2714